ArticleJournal of autism and developmental disorders2014
Melatonin in children with autism spectrum disorders: endogenous and pharmacokinetic profiles in relation to sleep.
Article in Journal of autism and developmental disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Status of research on the application of melatonin in insomnia based on bibliometric visualization analysis and development trends.Frontiers in psychiatry · 2025Pooled it
- Systematic Review of Sleep Disturbances and Circadian Sleep Desynchronization in Autism Spectrum Disorder: Toward an Integrative Model of a Self-Reinforcing Loop.Frontiers in psychiatry · 2019Pooled it
- Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial.Journal of autism and developmental disorders · 2022Trial
- Sleep Disturbances Differentially Associated With First and Second Language Receptive Vocabulary in Autistic Children.Journal of autism and developmental disorders · 2026Article
- Child and Family Characteristics as Predictors of the Severity of Self-injurious Behaviours in Autistic Children and Adolescents.Journal of autism and developmental disorders · 2026Article
- Medical comorbidities in autistic children: prevalence, sex-specific clustering, and network patterns at diagnosis in a Chilean cohort.European journal of pediatrics · 2026Article
- Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children.Autism : the international journal of research and practice · 2025Article
- Reply to Gringras et al. Comment on "Paditz et al. The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review.Children (Basel, Switzerland) · 2025Article
- Desperate for Sleep: Exploring Parental Perceptions of Melatonin Use Among Adolescents With Neurodevelopmental Disorders.Journal for specialists in pediatric nursing : JSPN · 2025Article
- Sleep Disorders in Children with Autism Spectrum Disorder: Developmental Impact and Intervention Strategies.Brain sciences · 2025Review
- The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Assessment of Serum Melatonin Levels, Sleep Patterns, and Clinical Symptoms in Children With Autism Spectrum Disorder: A Case-Control Study.Psychiatry investigation · 2025Article
- Sleep and circadian disturbances in children with neurodevelopmental disorders.Nature reviews. Neurology · 2025Review
- Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms.BMC medicine · 2025Review
- A Practice Pathway for the Treatment of Night Wakings in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2024Review
- A clinical-translational review of sleep problems in neurodevelopmental disabilities.Journal of neurodevelopmental disorders · 2024Review
- Sleep Problems, Circadian Rhythms, and Their Relation to Behavioral Difficulties in Children and Adolescents with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2024Article
- The Influence of Sleep Disorders on Neurobiological Structures and Cognitive Processes in Pediatric Population with ASD and Epilepsy: A Systematic Review.European journal of investigation in health, psychology and education · 2023Review
- Problems in the Development of the Sleep-Wake Rhythm Influence Neurodevelopmental Disorders in Children.Diagnostics (Basel, Switzerland) · 2023Review
- Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics.Neurobiology of sleep and circadian rhythms · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C(max)) and time to peak concentration (T(max)) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.