ArticlePsychopharmacology2014
Differential regulation of observational fear and neural oscillations by serotonin and dopamine in the mouse anterior cingulate cortex.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Psilocybin modulates social behaviour in male and female mice in a time-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- 5-HTZoological research · 2026Article
- Aberrant Fear: Biological Underpinnings Relevant to Psychosis, Antipsychotic Drugs, and Psychotherapeutic Treatments, a Translational Approach.International journal of molecular sciences · 2026Review
- Enhanced Fear Memory in Adult Male C57BL/6 Mice Following Low-Dose Isoflurane Exposure During Juvenile Development.Brain and behavior · 2025Article
- Cumulative Dopaminergic Genetic Effects on Empathy Development in Emerging Adults.Journal of youth and adolescence · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice.Nature communications · 2025Article
- Understanding Others' Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear.Advances in neurobiology · 2024Review
- Effects of systemic inflammation on the network oscillation in the anterior cingulate cortex and cognitive behavior.PloS one · 2024Article
- Partner-seeking and limbic dopamine system are enhanced following social loss in male prairie voles (Microtus ochrogaster).Genes, brain, and behavior · 2023Article
- Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interaction.PLoS biology · 2023Article
- Review
- Neural mechanisms of comforting: Prosocial touch and stress buffering.Hormones and behavior · 2023Review
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- Chronic nicotine impairs sparse motor learning via striatal fast-spiking parvalbumin interneurons.Addiction biology · 2021Article
- Reduced Consolation Behaviors in Physically Stressed Mandarin Voles: Involvement of Oxytocin, Dopamine D2, and Serotonin 1A Receptors Within the Anterior Cingulate Cortex.The international journal of neuropsychopharmacology · 2020Article
- Anxious Behavior of Adult CD1 Mice Perinatally Exposed to Low Concentrations of Ethanol Correlates With Morphological Changes in Cingulate Cortex and Amygdala.Frontiers in behavioral neuroscience · 2020Article
- Conserved features of anterior cingulate networks support observational learning across species.Neuroscience and biobehavioral reviews · 2019Review
- Bidirectional cingulate-dependent danger information transfer across rats.PLoS biology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe aberrant regulation of serotonin (5-HT) and dopamine (DA) in the brain has been implicated in neuropsychiatric disorders associated with marked impairments in empathy, such as schizophrenia and autism. Many psychiatric drugs bind to both types of receptors, and the anterior cingulate cortex (ACC) is known to be centrally involved with empathy. However, the relationship between the 5-HT/DA system in the ACC and empathic behavior is not yet well known.
objectivesWe investigated the role of 5-HT/DA in empathy-like behavior and in the regulation of ACC neural activity.
methodsAn observational fear learning task was conducted following microinjections of 5-HT, DA, 5-HT and DA, methysergide (5-HT receptor antagonist), SCH-23390 (DA D1 receptor antagonist), or haloperidol (DA D2 receptor antagonist) into the mouse ACC. The ACC neural activity influenced by 5-HT and DA was electrophysiologically characterized in vitro and in vivo.
resultsThe microinjection of haloperidol, but not methysergide or SCH-23390, decreased the fear response of observing mice. The administration of 5-HT and 5-HT and DA together, but not DA alone, reduced the freezing response of observing mice. 5-HT enhanced delta-band activity and reduced alpha- and gamma-band activities in the ACC, whereas DA reduced only alpha-band activity. Based on entropy, reduced complexity of ACC neural activity was observed with 5-HT treatment.
conclusionsThe current results demonstrated that DA D2 receptors in the ACC are required for observational fear learning, whereas increased 5-HT levels disrupt observational fear and alter the regularity of ACC neural oscillations.
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Registered trials
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