ArticlePsychopharmacology2014
The self-administration of rapidly delivered cocaine promotes increased motivation to take the drug: contributions of prior levels of operant responding and cocaine intake.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science.Addiction biology · 2022Trial
- The effects of exercise on generalized anxiety symptoms in adults: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2026Article
- Dissociation of intake and incentive sensitization during intermittent- and continuous-access heroin self-administration in rats.Psychopharmacology · 2025Article
- Intermittent access cocaine self-administration produces context-specific escalation and increased motivation.Drug and alcohol dependence · 2023Article
- Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum.The European journal of neuroscience · 2019Article
- Intermittent intake of rapid cocaine injections promotes the risk of relapse and increases mesocorticolimbic BDNF levels during abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats.Psychopharmacology · 2018Article
- Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
rationaleRapid drug delivery to the brain might increase the risk for developing addiction. In rats, increasing the speed of intravenous cocaine delivery (5 vs. 90 s) increases drug intake and the subsequent motivation to self-administer cocaine. Increased motivation for cocaine could result not only from more extensive prior drug intake and operant responding for drug, but also from neuroplasticity evoked by rapid drug uptake.
objectiveWe determined the contributions of prior drug intake and operant responding to the increased motivation for cocaine evoked by rapid delivery. We also investigated the effects of cocaine delivery speed on corticostriatal expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) mRNA.
methodsRats self-administered cocaine (0.25 mg/kg/infusion) delivered over 5 or 90 s during short-access (1 h/session; ShA) or long-access (6 h; LgA) sessions. Motivation for cocaine was then assessed by measuring responding under a progressive ratio schedule of reinforcement. Next, BDNF and TrkB mRNA levels were measured in 5- and 90-s rats.
resultsFive-second ShA and 5-s-LgA rats were more motivated for cocaine than their 90-s counterparts. This effect was dissociable from previous levels of drug intake or of operant responding for cocaine. In parallel, only rats self-administering rapid cocaine injections had altered BDNF and TrkB mRNA levels in corticostriatal regions.
conclusionsRapid drug delivery augments the motivation for cocaine independently of effects on the levels of drug intake or operant responding for drug. We suggest that rapid delivery might increase the motivation for drug by promoting neuroplasticity within reward pathways. This neuroplasticity could involve increased regulation of BDNF/TrkB.
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