ArticleBrain imaging and behavior2014
Heritable changes in regional cortical thickness with age.
Article in Brain imaging and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuroanatomical differences in obesity: meta-analytic findings and their validation in an independent dataset.International journal of obesity (2005) · 2019Pooled it
- Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group.Human brain mapping · 2017Pooled it
- FM-GPT: Bayesian fine mapping for phenome-wide transcriptome-wide association studies.PLoS genetics · 2026Article
- FM-GPT: Bayesian fine mapping for phenome-wide transcriptome-wide association studies.bioRxiv : the preprint server for biology · 2026Article
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- Genetic contributions to brain criticality and its relationship with human cognitive functions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- Heritability of functional gradients in the human subcortico-cortical connectivity.Communications biology · 2024Article
- Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes.Biostatistics (Oxford, England) · 2022Article
- Heritability of Functional Connectivity in Resting State: Assessment of the Dynamic Mean, Dynamic Variance, and Static Connectivity across Networks.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Morphological integration of the human brain across adolescence and adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Towards individualized cortical thickness assessment for clinical routine.Journal of translational medicine · 2020Article
- Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.Brain imaging and behavior · 2017Article
- The BDNF ValBehavioural brain research · 2017Article
- A seed-based cross-modal comparison of brain connectivity measures.Brain structure & function · 2017Article
- Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample: Role of Sex, Ethnicity, Puberty, and Alcohol Drinking.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Evidence from structural and diffusion tensor imaging for frontotemporal deficits in psychometric schizotypy.Schizophrenia bulletin · 2015Article
- Robust estimation of group-wise cortical correspondence with an application to macaque and human neuroimaging studies.Frontiers in neuroscience · 2015Article
- The rise of large-scale imaging studies in psychiatry.GigaScience · 2014Review
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Authors and funding
22 authors.
Funding
Abstract
It is now well established that regional indices of brain structure such as cortical thickness, surface area or grey matter volume exhibit spatially variable patterns of heritability. However, a recent study found these patterns to change with age during development, a result supported by gene expression studies. Changes in heritability have not been investigated in adulthood so far and could have important implications in the study of heritability and genetic correlations in the brain as well as in the discovery of specific genes explaining them. Herein, we tested for genotype by age (G ×A) interactions, an extension of genotype by environment interactions, through adulthood and healthy aging in 902 subjects from the Genetics of Brain Structure (GOBS) study. A "jackknife" based method for the analysis of stable cortical thickness clusters (JASC) and scale selection is also introduced. Although additive genetic variance remained constant throughout adulthood, we found evidence for incomplete pleiotropy across age in the cortical thickness of paralimbic and parieto-temporal areas. This suggests that different genetic factors account for cortical thickness heritability at different ages in these regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.