ArticleCurrent microbiology2014
Formic acid and acetic acid induce a programmed cell death in pathogenic Candida species.
Article in Current microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Intravaginal Combination Therapy of Acetic and Lactic Acid in premenopausal women with recurrent vulvovaginal candidiasis: A randomized, double-blind placebo-controlled feasibility trial.Women's health (London, England)Trial
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- Adjuvant Treatment Strategies for Acute Invasive Fungal Rhinosinusitis: An in Vitro Evaluation.Iranian journal of otorhinolaryngology · 2026Article
- Investigation into the Efficacy of Formic Acid Fumigation for Inactivating Clinically Isolated Filamentous Fungi.Infection and drug resistance · 2025Article
- Development and Characterization of Sodium Bicarbonate-Based Gel for Cytolytic Vaginosis.Pharmaceutics · 2024Article
- Fungal Apoptosis-Related Proteins.Microorganisms · 2024Review
- Induction of Apoptosis with Silver Nanoparticles Obtained Using Thermophilic Bacteria.Journal of functional biomaterials · 2024Article
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- An In Vitro Study of Chitosan-Coated Bovine Pericardium as a Dural Substitute Candidate.Journal of functional biomaterials · 2023Article
- Antimicrobial and mechanical properties of functionalized textile by nanoarchitectured photoinduced Ag@polymer coating.Beilstein journal of nanotechnology · 2023Article
- Ustilaginaceae Biocatalyst for Co-Metabolism of COJournal of fungi (Basel, Switzerland) · 2021Article
- Regulation of Cell Death Induced by Acetic Acid in Yeasts.Frontiers in cell and developmental biology · 2021Review
- Site-Specific Profiling of the Dental Mycobiome Reveals Strong Taxonomic Shifts during Progression of Early-Childhood Caries.Applied and environmental microbiology · 2020Article
- Identification of Growth Inhibitors of the Fish PathogenFrontiers in microbiology · 2020Article
- Cytosolic Acidification Is the First Transduction Signal of Lactoferrin-induced Regulated Cell Death Pathway.International journal of molecular sciences · 2019Article
- Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans.Scientific reports · 2019Article
- Cross-Domain and Viral Interactions in the Microbiome.Microbiology and molecular biology reviews : MMBR · 2019Review
- Daily Application of an Aqueous, Acidifying, Peelable Nail Polish versus Weekly Amorolfine for Topical Onychomycosis Treatment: A Prospective, Randomized, Blinded Trial.Dermatology and therapy · 2018Article
- Pulsed Electromagnetic Field Assisted in vitro Electroporation: A Pilot Study.Scientific reports · 2016Article
- Phenotypic switching of Candida guilliermondii is associated with pseudohyphae formation and antifungal resistance.Mycopathologia · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous fungal infections are common and widespread. Antifungal agents used for the treatment of these infections often have undesirable side effects. Furthermore, increased resistance of the microorganisms to the antifungal drugs becomes the growing problem. Accordingly, the search for natural antifungal compounds continues to receive attention. Apoptosis is highly regulated programmed cell death. During yeast cell apoptosis, amino acids and peptides are released and can stimulate regeneration of human epithelium cells. Thus, detection of chemical compounds inducing apoptosis in yeast and nontoxic for humans is of great medical relevance. The aim of this study was to detect chemical compound inducing apoptosis in pathogenic Candida species with the lowest toxicity to the mammalian cells. Five chemical compounds--acetic acid, sodium bicarbonate, potassium carbonate, lithium acetate, and formic acid--were tested for evaluation of antifungal activity on C. albicans, C. guilliermondii, and C. lusitaniae. The results showed that acetic acid and formic acid at the lowest concentrations induced yeast cells death. Apoptosis analysis revealed that cells death was accompanied by activation of caspase. Minimal inhibitory concentrations of potassium carbonate and sodium bicarbonate induced Candida cells necrosis. Toxicity test with mammalian cell cultures showed that formic acid has the lowest effect on the growth of Jurkat and NIH 3T3 cells. In conclusion, our results show that a low concentration of formic acid induces apoptosis-like programmed cell death in the Candida yeast and has a minimal effect on the survivability of mammalian cells, suggesting potential applications in the treatment of these infections.
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