Evidence map›Paper›PMID 24752469›Full record

ArticleMuscle & nerve2014

Electrical impedance myography for the in vivo and ex vivo assessment of muscular dystrophy (mdx) mouse muscle.

Jia Li, Tom R Geisbush, Glenn D Rosen, Jennifer Lachey, Aaron Mulivor, Seward B Rutkove

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Muscle & nerve, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 60 citations in OpenAlex.

  1. Inter-session reliability of electrical impedance myography in children in a clinical trial setting.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2015
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  15. Electrical Impedance Methods in Neuromuscular Assessment: An Overview.Cold Spring Harbor perspectives in medicine · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jia LiDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC-810, Boston, Massachusetts, 02215, USA.
Tom R Geisbush
Glenn D Rosen
Jennifer Lachey
Aaron Mulivor
Seward B Rutkove
Acceleron Pharma (United States) · USBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Electrical Impedance Myography in an Animal ModelR01NS055099 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2007 to 2022
$5.1M
NINDS NIH HHS R01 NS055099
6 · The paper itself

Abstract

introductionSensitive, non-invasive techniques are needed that can provide biomarkers of disease status and the effects of therapy in muscular dystrophy.

methodsWe evaluated electrical impedance myography (EIM) to serve in this role by studying 2-month-old and 18-month-old mdx and wild-type (WT) animals (10 animals in each of 4 groups).

resultsMarked differences were observed in EIM values between mdx and WT animals; the differences were more pronounced between the older age groups (e.g., reactance of 92.6 ± 4.3 Ω for mdx animals vs. 130 ± 4.1 Ω for WT animals, P<0.001). In addition, in vivo EIM parameters correlated significantly with the extent of connective tissue deposition in the mdx animals.

conclusionsEIM has the potential to serve as a valuable non-invasive method for evaluating muscular dystrophy. It can be a useful biomarker to assist with therapeutic testing in both pre-clinical and clinical studies.

Indexed as

Electric ImpedanceAge FactorsAnimalsBiomarkersDisease Models, AnimalElectromyographyHydroxyprolineMaleMiceMice, Inbred C57BLMice, Inbred mdxMuscle, SkeletalMuscular DystrophiesBiomarkersHydroxyprolinebiomarkerconnective tissueDuchenne muscular dystrophyelectrical impedancemdx mouse

Identifiers

PMID24752469
PMCPMC5582805
OpenAlexW1518036245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.