ArticlePloS one2014
Hybridization capture reveals evolution and conservation across the entire Koala retrovirus genome.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Contrasting segregation patterns among endogenous retroviruses across the koala population.Communications biology · 2024Article
- A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Expansion of a retrovirus lineage in the koala genome.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genomic Approaches for Conservation Management in Australia under Climate Change.Life (Basel, Switzerland) · 2021Review
- The virus-host interface: Molecular interactions of Alphacoronavirus-1 variants from wild and domestic hosts with mammalian aminopeptidase N.Molecular ecology · 2021Article
- Phylogenetic and geographical analysis of a retrovirus during the early stages of endogenous adaptation and exogenous spread in a new host.Molecular ecology · 2021Article
- Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review.Archives of virology · 2020Review
- Helping koalas battle disease - Recent advances in Chlamydia and koala retrovirus (KoRV) disease understanding and treatment in koalas.FEMS microbiology reviews · 2020Review
- Infectious Wildlife Diseases in Austria-A Literature Review From 1980 Until 2017.Frontiers in veterinary science · 2020Review
- Sequence capture using AFLP-generated baits: A cost-effective method for high-throughput phylogenetic and phylogeographic analysis.Ecology and evolution · 2019Article
- Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Transmission, Evolution, and Endogenization: Lessons Learned from Recent Retroviral Invasions.Microbiology and molecular biology reviews : MMBR · 2018Review
- Article
- Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species.Molecular ecology · 2017Article
- Phylogenetic Diversity of Koala Retrovirus within a Wild Koala Population.Journal of virology · 2017Article
- Targeted capture enrichment assay for non-invasive prenatal testing of large and small size sub-chromosomal deletions and duplications.PloS one · 2017Article
- Whole-genome fetal and maternal DNA methylation analysis using MeDIP-NGS for the identification of differentially methylated regions.Genetics research · 2016Article
- Endogenous Gibbon Ape Leukemia Virus Identified in a Rodent (Melomys burtoni subsp.) from Wallacea (Indonesia).Journal of virology · 2016Article
- Sequence capture by hybridization to explore modern and ancient genomic diversity in model and nonmodel organisms.Nucleic acids research · 2016Review
- Episodic Diversifying Selection Shaped the Genomes of Gibbon Ape Leukemia Virus and Related Gammaretroviruses.Journal of virology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The koala retrovirus (KoRV) is the only retrovirus known to be in the midst of invading the germ line of its host species. Hybridization capture and next generation sequencing were used on modern and museum DNA samples of koala (Phascolarctos cinereus) to examine ca. 130 years of evolution across the full KoRV genome. Overall, the entire proviral genome appeared to be conserved across time in sequence, protein structure and transcriptional binding sites. A total of 138 polymorphisms were detected, of which 72 were found in more than one individual. At every polymorphic site in the museum koalas, one of the character states matched that of modern KoRV. Among non-synonymous polymorphisms, radical substitutions involving large physiochemical differences between amino acids were elevated in env, potentially reflecting anti-viral immune pressure or avoidance of receptor interference. Polymorphisms were not detected within two functional regions believed to affect infectivity. Host sequences flanking proviral integration sites were also captured; with few proviral loci shared among koalas. Recently described variants of KoRV, designated KoRV-B and KoRV-J, were not detected in museum samples, suggesting that these variants may be of recent origin.
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Registered trials
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