ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2014
Depression in silent lacunar infarction: a cross-sectional study of its association with location of silent lacunar infarction and vascular risk factors.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis.Neuropsychology review · 2017Pooled it
- Trial
- A comparative study of interhemispheric functional connectivity in patients with basal ganglia ischemic stroke.Frontiers in aging neuroscience · 2024Article
- Application of machine learning model to predict lacunar cerebral infarction in elderly patients with femoral neck fracture before surgery.BMC geriatrics · 2022Article
- Initiation of antidepressants in young adults after ischemic stroke: a registry-based follow-up study.Journal of neurology · 2022Article
- DAPT score: predictive model of dual-antiplatelet therapy for acute cerebral infarction.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression.Neuropsychiatric disease and treatment · 2021Article
- Increased risk of cognitive impairment and more severe brain lesions in hypertensive compared to non-hypertensive patients with cerebral small vessel disease.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Vascular depression consensus report - a critical update.BMC medicine · 2016Article
- Neuropsychiatric sequelae of stroke.Nature reviews. Neurology · 2016Review
- The prevalence of lacunar infarct decreases with aging in the elderly: a case-controlled analysis.Clinical interventions in aging · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Most previous studies reported a close link between fresh infarcts and post-stroke depression. However, studies on the relation of depression and silent lacunar infarction (SLI) are limited. This study aims to analyze the effects of SLI and the vascular risk factors on depression. A total of 243 patients with SLI were divided into depression and non-depression groups. The presence and location of SLI were evaluated with magnetic resonance imaging. Depression was assessed with the Patient Health Questionnaire-9 and vascular risks factors were collected. We used t tests and χ (2) test to compare the baseline characteristics of the two groups and the multivariate logistic regression model to identify the risk factors for depression. Univariate analysis results showed that the proportion of patients with SLI in basal ganglia was significantly higher in the depression group (65.0 versus 32.8 %; P < 0.001) than in the non-depression group, and multiple prevalent factors had significant differences between the two groups. However, on multivariate logistic analysis, some of these factors were eliminated, and SLI in basal ganglia remained an independent predictor of depression with an odds ratio of 3.128 (P = 0.018). In addition, vascular risk factors, including high body mass index level, presence of inflammation markers (e.g., CRP, TNF-α, Hs-CRP, and IL-6), and lack of physical activity, were associated with depression. Our findings suggest that SLI in basal ganglia is associated with a higher risk of depression. Vascular risk factors, which are intertwined, may propose the pathological basis of depression in SLI.
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