ArticleAntimicrobial agents and chemotherapy2014
The mecA homolog mecC confers resistance against β-lactams in Staphylococcus aureus irrespective of the genetic strain background.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 80 citations in OpenAlex.
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- Distribution and characteristics of methicillin-resistant staphylococci from non-clinical environments in southern Vietnam.BMC microbiology · 2026Article
- Genotypic characterization of antibiotic resistance genes in multidrug-resistantVeterinary world · 2026Article
- Synergistic Effects of Thymoquinone, 3-Hydrazinoquinoxaline-2-Thiol, and Amphotericin B Against Methicillin-ResistantInternational journal of general medicine · 2026Article
- Multidrug resistance including borderline-oxacillin resistance and spa typing of Staphylococcus aureus from milk and milk products of Tigray region, Northern Ethiopia.BMC veterinary research · 2025Article
- Unveiling the synergistic power of 3-hydrazinoquinoxaline-2-thiol and vancomycin against MRSA: AnBiomolecules & biomedicine · 2025Article
- Molecular detection of blaTEM-encoding genes in multidrug-resistant EscherichiaOpen veterinary journal · 2025Article
- Hospital-associated MRSA genotypes causing complicated community-onset skin and musculoskeletal infections.Frontiers in cellular and infection microbiology · 2025Article
- Antimicrobial resistance, virulence profiling, and drug repurposing analysis of Staphylococcus aureus from camel mastitis.Veterinary research communications · 2024Article
- Development of a clinical metagenomics workflow for the diagnosis of wound infections.BMC medical genomics · 2024Article
- Article
- Molecular detection of extended-spectrum β-lactamase-producingOpen veterinary journal · 2024Article
- Molecular Determinants of β-Lactam Resistance in Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Review
- Phenotypic and Genotypic Characterization of Methicillin Resistance inPathogens (Basel, Switzerland) · 2023Article
- Evidence-based identification and characterization of methicillin-resistantIranian journal of veterinary research · 2023Article
- An Interplay of Multiple Positive and Negative Factors Governs Methicillin Resistance in Staphylococcus aureus.Microbiology and molecular biology reviews : MMBR · 2022Review
- Detection of Resistant and Enterotoxigenic Strains ofFoods (Basel, Switzerland) · 2022Article
- Impact of the Stringent Stress Response on the Expression of Methicillin Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Detection of Antimicrobial Resistance of BacteriaAntibiotics (Basel, Switzerland) · 2021Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
In staphylococci, methicillin resistance is mediated by mecA-encoded penicillin-binding protein 2a (PBP2a), which has a low affinity for beta-lactams. Recently, a novel PBP2a homolog was described as being encoded by mecC, which shares only 70% similarity to mecA. To prove that mecC is the genetic determinant that confers methicillin resistance in Staphylococcus aureus, a mecC knockout strain was generated. The S. aureus ΔmecC strain showed considerably reduced oxacillin and cefoxitin MICs (0.25 and 4 μg/ml, respectively) compared to those of the corresponding wild-type methicillin-resistant S. aureus (MRSA) strain (8 and 16 μg/ml, respectively). Complementing the mutant in trans with wild-type mecC restored the resistance to oxacillin and cefoxitin. By expressing mecC and mecA in different S. aureus clonal lineages, we found that mecC mediates resistance irrespective of the genetic strain background, yielding oxacillin and cefoxitin MIC values comparable to those with mecA. In addition, we showed that mecC expression is inducible by oxacillin, which supports the assumption that a functional beta-lactam-dependent regulatory system is active in MRSA strains possessing staphylococcal cassette chromosome mec (SCCmec) type XI. In summary, we showed that mecC is inducible by oxacillin and mediates beta-lactam resistance in SCCmec type XI-carrying strains as well as in different S. aureus genetic backgrounds. Furthermore, our results could explain the comparatively low MICs for clinical mecC-harboring S. aureus isolates.
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