ReviewNeurobiology of learning and memory2015
Covert rapid action-memory simulation (CRAMS): a hypothesis of hippocampal-prefrontal interactions for adaptive behavior.
Review in Neurobiology of learning and memory, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed.
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- Disrupted flexible use of context-dependent relational memory in adults following moderate-severe traumatic brain injury.Neuropsychologia · 2025Article
- Choice Behaviors and Prefrontal-Hippocampal Coupling Are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Deliberative Behaviors and Prefrontal-Hippocampal Coupling are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.bioRxiv : the preprint server for biology · 2024Article
- Goal-Dependent Hippocampal Representations Facilitate Self-Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Extended trajectory of spatial memory errors in typical and atypical development: The role of binding and precision.Hippocampus · 2023Article
- Back to the future: Progressing memory research in eating disorders.The International journal of eating disorders · 2023Article
- Dynamic interactions between memory and viewing behaviors: Insights from dyadic modeling of eye movements.Journal of experimental psychology. Human perception and performance · 2023Article
- Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability.Human brain mapping · 2023Article
- Mixing memory and desire: How memory reactivation supports deliberative decision-making.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Computational validity: using computation to translate behaviours across species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Looking for the neural basis of memory.Trends in cognitive sciences · 2022Review
- To learn or to gain: neural signatures of exploration in human decision-making.Brain structure & function · 2022Article
- Article
- Rapid coordination of effective learning by the human hippocampus.Science advances · 2021Article
- Spatial encoding in dorsomedial prefrontal cortex and hippocampus is related during deliberation.Hippocampus · 2020Article
- Dorsomedial prefrontal cortex and hippocampus represent strategic context even while simultaneously changing representation throughout a task session.Neurobiology of learning and memory · 2020Article
- "Chasing the first high": memory sampling in drug choice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Neural signatures underlying deliberation in human foraging decisions.Cognitive, affective & behavioral neuroscience · 2019Article
- Structural and Functional MRI Evidence for Distinct Medial Temporal and Prefrontal Roles in Context-dependent Relational Memory.Journal of cognitive neuroscience · 2019Article
Corrections and comments
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3 authors.
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Abstract
Effective choices generally require memory, yet little is known regarding the cognitive or neural mechanisms that allow memory to influence choices. We outline a new framework proposing that covert memory processing of hippocampus interacts with action-generation processing of prefrontal cortex in order to arrive at optimal, memory-guided choices. Covert, rapid action-memory simulation (CRAMS) is proposed here as a framework for understanding cognitive and/or behavioral choices, whereby prefrontal-hippocampal interactions quickly provide multiple simulations of potential outcomes used to evaluate the set of possible choices. We hypothesize that this CRAMS process is automatic, obligatory, and covert, meaning that many cycles of action-memory simulation occur in response to choice conflict without an individual's necessary intention and generally without awareness of the simulations, leading to adaptive behavior with little perceived effort. CRAMS is thus distinct from influential proposals that adaptive memory-based behavior in humans requires consciously experienced memory-based construction of possible future scenarios and deliberate decisions among possible future constructions. CRAMS provides an account of why hippocampus has been shown to make critical contributions to the short-term control of behavior, and it motivates several new experimental approaches and hypotheses that could be used to better understand the ubiquitous role of prefrontal-hippocampal interactions in situations that require adaptively using memory to guide choices. Importantly, this framework provides a perspective that allows for testing decision-making mechanisms in a manner that translates well across human and nonhuman animal model systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.