ReviewCurrent opinion in obstetrics & gynecology2014
Use of fertility drugs and risk of ovarian cancer.
Review in Current opinion in obstetrics & gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Association between ovarian tumors and exposure to assisted reproductive technologies and ovarian stimulation: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- Acupuncture for infertile women without undergoing assisted reproductive techniques (ART): A systematic review and meta-analysis.Medicine · 2019Pooled it
- Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility.The Cochrane database of systematic reviews · 2019Pooled it
- Clinical Investigation of Recurrence, Oncological, and Obstetrical Outcomes in Patients with Ovarian Atypical Endometriosis.Journal of clinical medicine · 2025Article
- Management of a Nulliparous IVF Patient with a Declined Ovarian Reserve After Discovery of an Atypical Ovarian Endometriotic Cyst.International journal of women's health · 2023Article
- Repeated hyperstimulation affects the ultrastructure of mouse fallopian tube epithelium.The Journal of reproduction and development · 2020Article
- Metastatic Ovarian Clear Cell Carcinoma in the Context ofCase reports in obstetrics and gynecology · 2020Article
- Granulosa-cell tumor after ovarian stimulation: A case report.International journal of reproductive biomedicine · 2018Article
- Reversal of tubo-ovarian atypical epithelial patterns after cessation of ovarian stimulation by letrozole.International journal of experimental pathology · 2016Article
- Chinese Herbal Products for Female Infertility in Taiwan: A Population-Based Cohort Study.Medicine · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThe purpose of this review is to highlight recent research and insights into the relationship between fertility drug use and ovarian cancer risk. RECENT
findingsResults from two large case-control studies provided further evidence that fertility drug use does not significantly contribute to risk of ovarian cancer among the majority of women when adjusting for known confounding factors. However, questions regarding the effect on certain subgroups, including long-term fertility drug users, women who remain nulligravid after fertility treatment, women with BRCA1 or BRCA2 mutations and borderline ovarian tumours, still remain. In addition, it may currently just be too early to determine whether there is an association between fertility drug use and ovarian cancer risk given that many of the exposed women are only now beginning to reach the ovarian cancer age range. SUMMARY: Whether use of fertility drugs increases the risk of ovarian cancer is an important question that requires further investigation, in particular given the large number of women utilizing fertility treatments. Fortunately, results from recent studies have been mainly reassuring. Large well designed studies with sufficient follow-up time are needed to further evaluate the effects of fertility treatments within subgroups defined by patient and tumour characteristics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.