ReviewPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2014
Time for a neonatal-specific consensus definition for sepsis.
Review in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
130 citing papers in PubMed, 8 syntheses or guidelines pooled it, 302 citations in OpenAlex.
- Antibiotic regimens for early-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Antibiotic regimens for late-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Core outcomes in neonatology: development of a core outcome set for neonatal research.Archives of disease in childhood. Fetal and neonatal edition · 2020Pooled it
- Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in immunology · 2020Pooled it
- Effects of immunotherapy on mortality in neonates with suspected or proven sepsis: a systematic review and network meta-analysis.BMC pediatrics · 2019Pooled it
- Community-based antibiotic delivery for possible serious bacterial infections in neonates in low- and middle-income countries.The Cochrane database of systematic reviews · 2019Pooled it
- Pooled it
- Guideline
- Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.PloS one · 2020Trial
- Antibiotic Overuse in Premature Low Birth Weight Infants in a Developing Country.The Pediatric infectious disease journal · 2019Trial
- Heterogeneity of Critical Organ Dysfunction During Late-Onset Bacteremia in Preterm Infants.JAMA network open · 2026Observational
- Exploratory Hemodynamic and Hematologic Trajectories by Culture Status Among Neonates Evaluated for Infection.Children (Basel, Switzerland) · 2026Article
- What's in a name? The critical importance of definitions in clinical medicine.Pediatric research · 2026Article
- A comparison between early onset sepsis (EOS) risk calculator and modified new protocol in a newborn ≥ 35 weeks: a simulation study.Italian journal of pediatrics · 2026Observational
- Systemic inflammatory mediators and neurodevelopmental outcomes in term infants: a retrospective cohort study.BMC pediatrics · 2026Article
- Systems biology approaches to unravelling neonatal sepsis and potential for precision diagnostics and therapeutics.Frontiers in pharmacology · 2026Review
- Application of Umbilical Cord Blood for the Clinical Prevention and Treatment of Complications in Preterm Infants(Review).Stem cell reviews and reports · 2026Review
- The utility of C-reactive protein in neonatal early-onset sepsis screening: A territory-wide cohort analysis.Pediatric investigation · 2025Article
- InfEHR: Clinical phenotype resolution through deep geometric learning on electronic health records.Nature communications · 2025Article
- Consequences of host-microbiome interactions in preterm infants.Infection and immunity · 2025Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of neonatal sepsis used. STUDY SELECTION: The review focused primarily on pediatric literature relevant to the topic of interest.
conclusionsNeonatal sepsis is variably defined based on a number of clinical and laboratory criteria that make the study of this common and devastating condition very difficult. Diagnostic challenges and uncertain disease epidemiology necessarily result from a variable definition of disease. In 2005, intensivists caring for children recognized that as new drugs became available, children would be increasingly studied and thus, pediatric-specific consensus definitions were needed. Pediatric sepsis criteria are not accurate for term neonates and have not been examined in preterm neonates for whom the developmental stage influences aberrations associated with host immune response. Thus, specific consensus definitions for both term and preterm neonates are needed. Such definitions are critical for the interpretation of observational studies, future training of scientists and practitioners, and implementation of clinical trials in neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.