ArticleThe Journal of investigative dermatology2014
Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation.
Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Evolution of an amphibian-specific family of epidermal differentiation-associated genes.Molecular biology and evolution · 2026Article
- Direct Effects of 308-nm Excimer Light on Keratinocyte Proliferation and Differentiation in Human Organ-Cultured Skin.International journal of molecular sciences · 2026Article
- Article
- Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes.Journal of biomedical science · 2025Article
- Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs.BMC genomics · 2023Article
- Heme Oxygenase-1 Is Upregulated during Differentiation of Keratinocytes but Its Expression Is Dispensable for Cornification of Murine Epidermis.Journal of developmental biology · 2023Article
- Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin.Frontiers in immunology · 2023Article
- Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients.Scientific reports · 2021Article
- The first case of a mosaic superficial epidermolytic ichthyosis diagnosed by Ultra-Deep Sequence.Molecular genetics & genomic medicine · 2020Article
- Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes.Scientific reports · 2020Article
- Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals.Scientific reports · 2019Article
- Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals.Molecular biology and evolution · 2019Article
- Establishment of keratinocyte cell lines from human hair follicles.Scientific reports · 2018Article
- Immunomodulatory role of Keratin 76 in oral and gastric cancer.Nature communications · 2018Article
- Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis.Scientific reports · 2017Article
- Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics.Cold Spring Harbor perspectives in biology · 2017Review
- Senescent Atrophic Epidermis Retains Lrig1+ Stem Cells and Loses Wnt Signaling, a Phenotype Shared with CD44KO Mice.PloS one · 2017Article
- Article
- The importance of ctokeratins in the early detection of oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratin K2 is one of the most abundant structural proteins of the epidermis; however, its biological significance has remained elusive. Here we show that suprabasal type II keratins, K1 and K2, are expressed in a mutually exclusive manner at different body sites of the mouse, with K2 being confined to the ear, sole, and tail skin. Deletion of K2 caused acanthosis and hyperkeratosis of the ear and the tail epidermis, corneocyte fragility, increased transepidermal water loss, and local inflammation in the ear skin. The loss of K2 was partially compensated by upregulation of K1 expression. However, a significant portion of K2-deficient suprabasal keratinocytes lacked a regular cytoskeleton and developed massive aggregates of the type I keratin, K10. Aggregate formation, but not hyperkeratosis, was suppressed by the deletion of both K2 and K10, whereas deletion of K10 alone caused clumping of K2 in ear skin. Taken together, this study demonstrates that K2 is a necessary and sufficient binding partner of K10 at distinct body sites of the mouse and that unbalanced expression of these keratins results in aggregate formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.