ArticleThe Journal of investigative dermatology2014
TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6.
Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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Who cites it
51 citing papers in PubMed, 117 citations in OpenAlex.
- High-salt microenvironment worsens the progression of atopic dermatitis via activating the SGK-1-mTOR pathway in keratinocytes.Genes & diseases · 2026Article
- Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin.Allergy · 2026Article
- Reticular Basement Membrane Remodelling Regulates Bronchial Epithelial Attachment, Barrier Integrity and Inflammatory Signalling in Asthma.Advances in respiratory medicine · 2026Article
- Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX-622.Allergy · 2025Article
- Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation.Science (New York, N.Y.) · 2025Article
- TSLP: contrasting roles in cancer.Frontiers in immunology · 2025Review
- Epithelial-derived cytokines in the pathogenesis of severe asthma.Frontiers in allergy · 2025Review
- Upper Airway Alarmin Cytokine Expression in Asthma of Different Severities.Journal of clinical medicine · 2024Article
- Tezepelumab for Severe Asthma: One Drug Targeting Multiple Disease Pathways and Patient Types.Journal of asthma and allergy · 2024Review
- Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma.International journal of molecular sciences · 2023Review
- Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- The Protective Effect of a Functional Food Consisting ofFoods (Basel, Switzerland) · 2023Article
- The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target.Mediators of inflammation · 2023Review
- Potential Therapeutic Skin Microbiomes SuppressingInternational journal of molecular sciences · 2022Article
- Mast Cell Activation Syndrome in COVID-19 and Female Reproductive Function: Theoretical Background vs. Accumulating Clinical Evidence.Journal of immunology research · 2022Review
- Alarmin Cytokines as Central Regulators of Cutaneous Immunity.Frontiers in immunology · 2022Review
- Ginsenoside Rg3 attenuates skin disorders via down-regulation of MDM2/HIF1α signaling pathway.Journal of ginseng research · 2021Article
- Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.Nature communications · 2021Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thymic stromal lymphopoietin (TSLP) is known to promote T helper type 2 cell-associated inflammation. Mast cells are major effector cells in allergic inflammatory responses. We noted that the population and maturation of mast cells were reduced in TSLP-deficient mice (TSLP-/-). Thus, we hypothesized that TSLP might affect mast cell development. We found that TSLP induced the proliferation and differentiation of mast cells from bone marrow progenitors. TSLP-induced mast cell proliferation was abolished by depletion of mouse double minute 2 (MDM2) and signal transducers and activators of transcription 6 (STAT6), as an upstream activator of MDM2. TSLP-/-, in particular, had a considerable deficit in the expression of MDM2 and STAT6. Also, the TSLP deficiency attenuated mast cell-mediated allergic reactions through the downregulation of STAT6 and MDM2. In an antibody microarray chip analysis, MDM2 expression was increased in atopic dermatitis patients. These observations indicate that TSLP is a factor for mast cell development, and that it aggravates mast cell-mediated immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.