ArticleMechanisms of development2014
Novel expression of EGFL7 in placental trophoblast and endothelial cells and its implication in preeclampsia.
Article in Mechanisms of development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Late-Onset Preeclampsia Is Linked to Extensive Remodeling of the Placental Extracellular Matrix.Medical sciences (Basel, Switzerland) · 2026Observational
- Effect of Pravastatin on Placental Expression of Epidermal Growth Factor-like Domain 7 in Early-Onset Pre-Eclampsia: A New Potential Mechanism of Action.Biomedicines · 2024Article
- Trans-differentiation of trophoblast stem cells: implications in placental biology.Life science alliance · 2023Article
- Evaluation Of Epidermal Growth Factor-Like Domain (EGFL7) mRNA Expression and its Protein Level in Preeclampsia.Journal of obstetrics and gynaecology of India · 2023Article
- Placental Dysfunction in Assisted Reproductive Pregnancies: Perinatal, Neonatal and Adult Life Outcomes.International journal of molecular sciences · 2022Review
- Article
- Circulating EGFL7 distinguishes between IUGR and PE: an observational case-control study.Scientific reports · 2021Observational
- An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level.Molecular medicine reports · 2021Observational
- Expression and significance of microRNA-126 and VCAM-1 in placental tissues of women with early-onset preeclampsia.The journal of obstetrics and gynaecology research · 2021Article
- Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migration.Reproduction (Cambridge, England) · 2021Article
- Placental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain.International journal of obesity (2005) · 2020Article
- Review
- Molecular Signaling Regulating Endometrium-Blastocyst Crosstalk.International journal of molecular sciences · 2019Review
- Increased circulating levels of Epidermal Growth Factor-like Domain 7 in pregnant women affected by preeclampsia.Translational research : the journal of laboratory and clinical medicine · 2019Article
- miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta.Developmental biology · 2019Article
- Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation.Biology open · 2019Article
- Secondary Placental Defects inFrontiers in physiology · 2019Article
- Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Article
- Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice withDevelopment (Cambridge, England) · 2017Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
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Abstract
The mammalian placenta is the site of nutrient and gas exchange between the mother and fetus, and is comprised of two principal cell types, trophoblasts and endothelial cells. Proper placental development requires invasion and differentiation of trophoblast cells, together with coordinated fetal vasculogenesis and maternal vascular remodeling. Disruption in these processes can result in placental pathologies such as preeclampsia (PE), a disease characterized by late gestational hypertension and proteinuria. Epidermal Growth Factor Like Domain 7 (EGFL7) is a largely endothelial-restricted secreted factor that is critical for embryonic vascular development, and functions by modulating the Notch signaling pathway. However, the role of EGFL7 in placental development remains unknown. In this study, we use mouse models and human placentas to begin to understand the role of EGFL7 during normal and pathological placentation. We show that Egfl7 is expressed by the endothelium of both the maternal and fetal vasculature throughout placental development. Importantly, we uncovered a previously unknown site of EGFL7 expression in the trophoblast cell lineage, including the trophectoderm, trophoblast stem cells, and placental trophoblasts. Our results demonstrate significantly reduced Egfl7 expression in human PE placentas, concurrent with a downregulation of Notch target genes. Moreover, using the BPH/5 mouse model of PE, we show that the downregulation of Egfl7 in compromised placentas occurs prior to the onset of characteristic maternal signs of PE. Together, our results implicate Egfl7 as a possible factor in normal placental development and in the etiology of PE.
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Registered trials
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