ArticleScientific reports2014
On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Advanced cardiotoxicity profiling using field potential imaging with UHD-CMOS-MEA in human iPSC-derived cardiomyocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Electrophysiological analysis of hyperkalemic cardiomyocytes using a multielectrode array system.Biophysics and physicobiology · 2024Article
- Importance of Spatial Arrangement of Cardiomyocyte Network for Precise and Stable On-Chip Predictive Cardiotoxicity Measurement.Micromachines · 2023Article
- Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.Circulation · 2023Article
- Rianú: Multi-tissue tracking software for increased throughput of engineered cardiac tissue screening.Computer methods and programs in biomedicine update · 2023Article
- Photothermal Agarose Microfabrication Technology for Collective Cell Migration Analysis.Micromachines · 2021Article
- Stepwise neuronal network pattern formation in agarose gel during cultivation using non-destructive microneedle photothermal microfabrication.Scientific reports · 2021Article
- Geometric Understanding of Local Fluctuation Distribution of Conduction Time in Lined-Up Cardiomyocyte Network in Agarose-Microfabrication Multi-Electrode Measurement Assay.Micromachines · 2020Article
- Dynamic Properties of Heart Fragments from Different Regions and Their Synchronization.Bioengineering (Basel, Switzerland) · 2020Article
- Dominant rule of community effect in synchronized beating behavior of cardiomyocyte networks.Biophysical reviews · 2020Review
- Biophysics at Waseda University.Biophysical reviews · 2020Article
- Modeling ofCells · 2019Article
- Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system.Biomaterials · 2018Article
- On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development.Scientific reports · 2018Article
- Conceptual Design of Micro-Bioreactors and Organ-on-Chips for Studies of Cell Cultures.Bioengineering (Basel, Switzerland) · 2018Review
- Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation.International journal of molecular sciences · 2017Article
- Tailoring cardiac environment in microphysiological systems: an outlook on current and perspective heart-on-chip platforms.Future science OA · 2017Article
- Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip.Biomaterials · 2016Article
- Biomaterial based cardiac tissue engineering and its applications.Biomedical materials (Bristol, England) · 2015Review
- Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters.PloS one · 2015Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To overcome the limitations and misjudgments of conventional prediction of arrhythmic cardiotoxicity, we have developed an on-chip in vitro predictive cardiotoxicity assay using cardiomyocytes derived from human stem cells employing a constructive spatiotemporal two step measurement of fluctuation (short-term variability; STV) of cell's repolarization and cell-to-cell conduction time, representing two origins of lethal arrhythmia. Temporal STV of field potential duration (FPD) showed a potential to predict the risks of lethal arrhythmia originated from repolarization dispersion for false negative compounds, which was not correctly predicted by conventional measurements using animal cells, even for non-QT prolonging clinical positive compounds. Spatial STV of conduction time delay also unveiled the proarrhythmic risk of asynchronous propagation in cell networks, whose risk cannot be correctly predicted by single-cell-based measurements, indicating the importance of the spatiotemporal fluctuation viewpoint of in vitro cell networks for precise prediction of lethal arrhythmia reaching clinical assessment such as thorough QT assay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.