Evidence map›Paper›PMID 24751304›Full record

Trial reportJournal of affective disorders2014

Effect of adjunctive benzodiazepines on clinical outcomes in lithium- or quetiapine-treated outpatients with bipolar I or II disorder: results from the Bipolar CHOICE trial.

William V Bobo, Noreen A Reilly-Harrington, Terence A Ketter, Benjamin D Brody, Gustavo Kinrys, David E Kemp, Richard C Shelton, Susan L McElroy, Louisa G Sylvia, James H Kocsis and 13 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. A retrospective record review and assessment of cost of quetiapine use in a community psychiatric setting in the Sedibeng district of Gauteng.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2017
    Article
  6. Risk of psychiatric disorders in patients with chronic insomnia and sedative-hypnotic prescription: a nationwide population-based follow-up study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 1 country.

William V BoboDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. Electronic address: bobo.william@mayo.edu.
Noreen A Reilly-HarringtonThe Massachusetts General Hospital, Boston, MA, USA.
Terence A KetterStanford University School of Medicine, Stanford, CA, USA.
Benjamin D BrodyWeill Cornell Medical College of Cornell University, New York, NY, USA.
Gustavo KinrysThe Massachusetts General Hospital, Boston, MA, USA.
David E KempCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Richard C SheltonUniversity of Alabama-Birmingham School of Medicine, Birmingham, AL, USA.
Susan L McElroyLindner Center for HOPE, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Louisa G SylviaThe Massachusetts General Hospital, Boston, MA, USA.
James H KocsisWeill Cornell Medical College of Cornell University, New York, NY, USA.
Melvin G McInnisUniversity of Michigan School of Medicine, Ann Arbor, MI, USA.
Edward S FriedmanUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Vivek SinghUniversity of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Mauricio TohenUniversity of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Charles L BowdenUniversity of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Thilo DeckersbachThe Massachusetts General Hospital, Boston, MA, USA.
Joseph R CalabreseCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Michael E ThasePerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Andrew A NierenbergThe Massachusetts General Hospital, Boston, MA, USA.
Dustin J RabideauThe Massachusetts General Hospital, Boston, MA, USA.
David A SchoenfeldThe Massachusetts General Hospital, Boston, MA, USA.
Stephen V FaraoneUpstate Medical University, State University of New York, Syracuse, NY, USA.
Masoud KamaliUniversity of Michigan School of Medicine, Ann Arbor, MI, USA.
Harvard University Press · USCornell University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Michigan · USUniversity School · USCalifornia University of Pennsylvania · USMayo Clinic · USStanford University · USSUNY Upstate Medical University · USUniversity of Alabama at Birmingham · USUniversity of Cincinnati · USUniversity of New Mexico · USUniversity of Pittsburgh · US

Funding

Comparative Effectiveness Study for Bipolar DisorderR01HS019371 · AHRQ · MASSACHUSETTS GENERAL HOSPITAL · PI NIERENBERG, ANDREW A · 2010 to 2010
$9.8M
Pharmacoepidemiology of Atypical Antipsychotic DrugsK23MH087747 · NIMH · VANDERBILT UNIVERSITY · PI BOBO, WILLIAM V · 2010 to 2013
$686k
AHRQ HHS R01 HS019371AHRQ HHS R01HS019371-01NIMH NIH HHS K23 MH087747NIMH NIH HHS MH087747
6 · The paper itself

Abstract

backgroundLittle is known about the longer-term effects of adjunctive benzodiazepines on symptom response during treatment in patients with bipolar disorders.

methodsThe study sample consisted of 482 patients with bipolar I or II disorder enrolled in a 6-month, randomized, multi-site comparison of lithium- and quetiapine-based treatment. Changes in clinical measures (BISS total and subscales, CGI-BP, and CGI-Efficacy Index) were compared between participants who did and did not receive benzodiazepine treatment at baseline or during follow-up. Selected outcomes were also compared between patients who did and did not initiate benzodiazepines during follow-up using stabilized inverse probability weighted analyses.

resultsSignificant improvement in all outcome measures occurred within each benzodiazepine exposure group. Benzodiazepine users (at baseline or during follow-up) experienced significantly less improvement in BISS total, BISS irritability, and CGI-BP scores than did benzodiazepine non-users. There were no significant differences in these measures between patients who did and did not initiate benzodiazepines during follow-up in the weighted analyses. There was no significant effect of benzodiazepine use on any outcome measure in patients with comorbid anxiety or substance use disorders. LIMITATIONS: This is a secondary analysis of data from a randomized effectiveness trial that was not designed to address differential treatment response according to benzodiazepine use.

conclusionsAdjunctive benzodiazepines may not significantly affect clinical outcome in lithium- or quetiapine-treated patients with bipolar I or II disorder over 6 months, after controlling for potential confounding factors.

Indexed as

AdultAntipsychotic AgentsBenzodiazepinesBipolar DisorderDibenzothiazepinesFemaleHumansLithium CompoundsMaleMiddle AgedQuetiapine FumarateTreatment OutcomeAntipsychotic AgentsBenzodiazepinesDibenzothiazepinesLithium CompoundsQuetiapine FumarateBenzodiazepinesBipolar disorderClinical outcomeLithiumQuetiapine

Identifiers

PMID24751304
PMCPMC4113323
OpenAlexW2038020766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.