ArticleCNS neuroscience & therapeutics2014
Use of statin during hospitalization improves the outcome after intracerebral hemorrhage.
Article in CNS neuroscience & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Recurrent stroke was associated with poor quality of life in patients with transient ischemic attack or minor stroke: finding from the CHANCE trial.CNS neuroscience & therapeutics · 2014 · on this mapTrial
- Unsupervised machine learning revealed a correlation between low-dose statins and favorable outcomes in ICH patients.Frontiers in neurology · 2025Article
- Intensive Versus Moderate Statin-Based Therapies in Patients With Mild Ischemic Stroke: A Prospective Multicenter Cohort Study.Journal of the American Heart Association · 2024Observational
- Article
- Effect of statin therapy patterns on readmission and mortality in patients with intracerebral hemorrhage.Journal of thrombosis and thrombolysis · 2024Article
- Statins and 90-Day Functional Performance and Survival in Patients with Spontaneous Intracerebral Hemorrhage.Journal of clinical medicine · 2023Article
- Brain edema formation and therapy after intracerebral hemorrhage.Neurobiology of disease · 2023Review
- Review
- Simvastatin Upregulates Lipoxin A4 and Accelerates Neuroinflammation Resolution After Intracerebral Hemorrhage.Current neurovascular research · 2022Article
- Statins on Spontaneous Intracerebral Hemorrhage: A Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Neuroprotective Therapies for Spontaneous Intracerebral Hemorrhage.Neurocritical care · 2021Review
- Role of Blood Lipid Levels and Lipid-Lowering Therapy in Stroke Patients with Different Levels of Cerebral Artery Diseases: Reconsidering Recent Stroke Guidelines.Journal of stroke · 2021Review
- Early in-hospital exposure to statins and outcome after intracerebral haemorrhage - Results from the Virtual International Stroke Trials Archive.European stroke journal · 2020Article
- Significant reduction in the LDL cholesterol increases the risk of intracerebral hemorrhage: a systematic review and meta-analysis of 33 randomized controlled trials.American journal of translational research · 2020Article
- Review
- Simvastatin Reduces Neutrophils Infiltration Into Brain Parenchyma After Intracerebral Hemorrhage via Regulating Peripheral Neutrophils Apoptosis.Frontiers in neuroscience · 2018Article
- Association between patient outcomes and key performance indicators of stroke care quality: A systematic review and meta-analysis.European stroke journal · 2017Review
- The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.Journal of neurology, neurosurgery, and psychiatry · 2017Review
- Statin Therapy and Risk of Intracranial Hemorrhage in Patients with Ischemic Stroke.Drug safety · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes.
methodsData were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional outcome and rate of mortality at 3 months and 1 year were compared between ICH patients on statin and those without it during their hospitalization. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated using the multivariable logistic regression model adjusted for baseline risk factors.
resultsAmong 3218 consecutive ICH patients from 2007 to 2008, 220 (6.8%) were on statin during their hospitalization. Compared with those without statin, patients on statin were younger, had more stroke risk factors but lower stroke severity. ICH patients on statin had better functional outcome at 3 months (OR 2.24, 95% CI 1.49-3.36) and at 1 year (OR 2.04, 95% CI 1.37-3.06). They also had lower rate of mortality at 3 months (OR 0.44, 95% CI 0.22-0.87) and 1 year (OR 0.49, 95% CI 0.27-0.86).
conclusionsIn-hospital statin use in ICH patients is associated with better functional outcome and lower mortality at 3 months and 1 year.
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