ArticleThe European journal of neuroscience2014
Role of lateral hypothalamus in two aspects of attention in associative learning.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Glutamatergic Heterogeneity in the Neuropeptide Projections From the Lateral Hypothalamus to the Mouse Olfactory Bulb.The Journal of comparative neurology · 2026Article
- Dual Role of LH-GABA Neurons in Encoding Alcohol Reward and Aversive Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- COPhysiology & behavior · 2023Article
- Altered Hypothalamic Functional Connectivity Following Total Sleep Deprivation in Young Adult Males.Frontiers in neuroscience · 2021Article
- Activation of medial hypothalamic orexin neurons during a Go/No-Go task.Brain research · 2020Article
- The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders.Psychopharmacology · 2018Review
- Weight gain after subthalamic nucleus deep brain stimulation in Parkinson's disease is influenced by dyskinesias' reduction and electrodes' position.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Observational
- Consolidation of altered associability information by amygdala central nucleus.Neurobiology of learning and memory · 2016Article
- Neural correlates of two different types of extinction learning in the amygdala central nucleus.Nature communications · 2016Article
- Orexin/hypocretin receptor 1 signaling mediates Pavlovian cue-food conditioning and extinction.Physiology & behavior · 2016Article
- Mini-review: Prediction errors, attention and associative learning.Neurobiology of learning and memory · 2016Review
- Orexin A-induced enhancement of attentional processing in rats: role of basal forebrain neurons.Psychopharmacology · 2016Article
- The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism.Cellular signalling · 2015Article
- Amygdalo-striatal interaction in the enhancement of stimulus salience in associative learning.Behavioral neuroscience · 2015Article
- Motivational activation: a unifying hypothesis of orexin/hypocretin function.Nature neuroscience · 2014Review
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
Orexin (hypocretin) and melanin-concentrating hormone (MCH) neurons are unique to the lateral hypothalamic (LH) region, but project throughout the brain. These cell groups have been implicated in a variety of functions, including reward learning, responses to stimulants, and the modulation of attention, arousal and the sleep/wakefulness cycle. Here, we examined roles for LH in two aspects of attention in associative learning shown previously to depend on intact function in major targets of orexin and MCH neurons. In experiments 1 and 2, unilateral orexin-saporin lesions of LH impaired the acquisition of conditioned orienting responses (ORs) and bilaterally suppressed FOS expression in the amygdala central nucleus (CeA) normally observed in response to food cues that provoke conditioned ORs. Those cues also induced greater FOS expression than control cues in LH orexin neurons, but not in MCH neurons. In experiment 3, unilateral orexin-saporin lesions of LH eliminated the cue associability enhancements normally produced by the surprising omission of an expected event. The magnitude of that impairment was positively correlated with the amount of LH damage and with the loss of orexin neurons in particular, but not with the loss of MCH neurons. We suggest that the effects of the LH orexin-saporin lesions were mediated by their effect on information processing in the CeA, known to be critical to both behavioral phenomena examined here. The results imply close relations between LH motivational amplification functions and attention, and may inform our understanding of disorders in which motivational and attentional impairments co-occur.
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