ArticleNeuropathology and applied neurobiology2015
Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin-like growth factor-1 signalling.
Article in Neuropathology and applied neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Can Environmental Enrichment Mitigate Cell Apoptosis in the Central Nervous System Under Adverse Health Conditions? A Systematic Review.Clinical and translational science · 2026Pooled it
- A Scoping Review of Preclinical Environmental Enrichment Protocols in Models of Poststroke to Set the Foundations for Translating the Paradigm to Clinical Settings.Translational stroke research · 2025Article
- Enriched environment as a nonpharmacological neuroprotective strategy.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Research progress of IGF-1 and cerebral ischemia.Ibrain · 2021Review
- Differential Effects of Physical and Social Enriched Environment on Angiogenesis in Male Rats After Cerebral Ischemia/Reperfusion Injury.Frontiers in human neuroscience · 2021Article
- Usnic acid improves memory impairment after cerebral ischemia/reperfusion injuries by anti-neuroinflammatory, anti-oxidant, and anti-apoptotic properties.Iranian journal of basic medical sciences · 2020Article
- Pharmacological Manipulation of Trk, p75NTR, and NGF Balance Restores Memory Deficit in Global Ischemia/Reperfusion Model in Rats.Journal of molecular neuroscience : MN · 2019Article
- Enriching Communicative Environments: Leveraging Advances in Neuroplasticity for Improving Outcomes in Neurogenic Communication Disorders.American journal of speech-language pathology · 2019Review
- Enriched Environment Promoted Cognitive FunctionFrontiers in neurology · 2019Article
- Sulfur dioxide reduces hippocampal cell death and improves learning and memory deficits in a rat model of transient global ischemia/reperfusion.Iranian journal of basic medical sciences · 2018Article
- Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Journal of veterinary science · 2018Article
- Nesfatin-1 Improve Spatial Memory Impairment Following Transient Global Cerebral Ischemia/Reperfusion via Inhibiting Microglial and Caspase-3 Activation.Journal of molecular neuroscience : MN · 2018Article
- Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long‑term maintenance of insulin‑like growth factor 1 and its receptors in the hippocampal CA1 region.Molecular medicine reports · 2018Article
- Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.Physiology & behavior · 2017Article
- An enriched environment and 17-beta estradiol produce similar pro-cognitive effects on ovariectomized rats.Cognitive processing · 2016Article
- Impact of Enriched Environment on Murine T Cell Differentiation and Gene Expression Profile.Frontiers in immunology · 2016Article
- Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats.BMC neuroscience · 2015Article
- Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
aimsUse of enriched environment (EE) housing has been shown to promote recovery from cerebral ischaemic injury but the underlying mechanisms of their beneficial effects remains unclear. Here we examined whether the beneficial effects of EE housing on ischaemia-induced neurodegeneration and cognitive impairment are associated with increased insulin-like growth factor-1 (IGF-1) signalling in the hippocampus.
methodsForty-two adult male Wistar rats were included in the study and received either ischaemia or sham surgery. Rats in each group were further randomized to either: EE or standard laboratory cage housing (control). Rats were placed in their assigned housing condition immediately after recovery from anaesthesia. Behavioural testing in the cued learning and discrimination learning tasks were conducted 2 weeks after ischaemia. Rats were euthanized after behavioural testing and the hippocampus was analysed for IGF-1 level, IGF-1 receptor (IGF-1R) activation, protein kinase B (Akt) pathway activation, neurone loss and caspase 3 expression.
resultsOur data showed that EE housing: (1) mitigated ischaemia-induced neuronal loss; (2) attenuated ischaemia-induced increase in caspase 3 immunoreactivity in the hippocampus; (3) ameliorated ischaemia-induced cognitive impairments; and (4) increased IGF-1R activation and signalling through the Akt pathway after ischaemic injury.
conclusionUltimately, these findings suggest the possibility that IGF-1 signalling may be one of the underlying mechanisms involved in the beneficial effects of EE in optimizing recovery following cerebral ischaemic injury.
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