SynthesisHeadache2014
Treatment adherence in patients with headache: a systematic review.
Synthesis in Headache, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of eptinezumab 300 mg with 100 mg for the treatment of migraine: a meta-analysis of randomized controlled studies.African health sciences · 2024Pooled it
- Electronic behavioral interventions for headache: a systematic review.The journal of headache and pain · 2016Pooled it
- A 52-week open-label extension study to evaluate the safety and efficacy of oral rimegepant for the preventive treatment of migraine.Headache · 2026Trial
- Effects of neck-exercise and health promotion on headache outcomes in office workers: secondary analysis of the NEXpro stepped wedge cluster randomised controlled trial.The journal of headache and pain · 2025Trial
- Multimodal Assessment of Medication Adherence Among Youth With Migraine: An Ancillary Study of the CHAMP Trial.Journal of pediatric psychology · 2022Trial
- Methylphenidate augmentation of escitalopram to enhance adherence to antidepressant treatment: a pilot randomized controlled trial.BMC psychiatry · 2021Trial
- Trial
- Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial.The Clinical journal of pain · 2017Trial
- Acute migraine medication adherence, migraine disability and patient satisfaction: A naturalistic daily diary study.Cephalalgia : an international journal of headache · 2017Trial
- Article
- Pharmacist-led migraine consultations in community pharmacies: a pilot study of pharmacists' experiences and patient-reported outcomes.The journal of headache and pain · 2026Article
- Early health technology assessment of a primary care tool for the diagnosis and management of headaches in Alberta, Canada.International journal of technology assessment in health care · 2026Article
- Adherence status and influencing factors of acute and preventive pharmacotherapy among migraine patients in China.The journal of headache and pain · 2025Article
- Migraine triggers and lifestyle modifications: an assessment of patients' awareness and the role of healthcare providers in patient education.The journal of headache and pain · 2025Article
- Implementing a digital solution for patients with migraine-Developing a methodology for comparing digitally delivered treatment with conventional treatment: A study protocol.PLOS digital health · 2024Article
- Treatment adherence: A Concept Analysis Using the Walker & Avant Method.Patient preference and adherence · 2024Review
- Neuromodulation for the Sphenopalatine Ganglion-a Narrative Review.Current pain and headache reports · 2023Review
- Medication adherence in patients with cluster headache and migraine: an online survey.Scientific reports · 2023Article
- Acceptability and Tolerability of Extended Reality Relaxation Training with and without Wearable Neurofeedback in Pediatric Migraine.Children (Basel, Switzerland) · 2023Article
- Aligning with Patients and Families: Exploring Youth and Caregiver Openness to Pediatric Headache Interventions.Children (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo review and critically evaluate the extant research literature pertaining to adherence in youth and adults with headache and to provide recommendations for future research.
backgroundThis article provides the first systematic review of pediatric headache adherence and updates a previous review of treatment adherence in adults with headache.
designSystematic review of empirical literature.
methodsA literature search with no date restriction was conducted using PubMed and PsycINFO electronic databases and bibliographies of relevant articles.
resultsAdherence rates in adults with headache range considerably from 25% to 94% across treatment, assessment method, and definition of adherence utilized. Methods to assess adherence included retrospective prescription claims data, paper or electronic diaries, follow-up appointment attendance, written and verbal self-report of general adherence, verbal self-report of adherence over a specific amount of time via in person interview or telephone, validated adherence measures, adherence questionnaires without validation, and counselor ratings of homework. Each methodology and assessment tool demonstrated strengths and weaknesses. No studies have systematically examined medication adherence in children with headache, and the few available studies examining adherence to behavioral treatment have documented adherence rates ranging from 52% to 86%.
conclusionsAdherence research in adults with headache is growing, but studies demonstrate a number of methodological shortcomings. Adherence research in children with headache, and adherence intervention research in both adults and children, is scant. Future research should use objective measures of adherence, consider over-the-counter medications and medication overuse, examine demographic, psychological, and behavioral correlates of adherence, assess adherence to botulinum toxin type A, and examine the efficacy of adherence interventions in individuals with headache.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.