ReviewBritish journal of pharmacology2014
Role of cues and contexts on drug-seeking behaviour.
Review in British journal of pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Problematic Gaming and Gambling: A Systematic Review of Task-Specific EEG Protocols.Journal of gambling studies · 2024Pooled it
- Topiramate decreases the salience of motivationally relevant visual cues among smokers with alcohol use disorder.Alcoholism, clinical and experimental research · 2022Trial
- Relationship between depression on cocaine craving over time amongst patients in a trial evaluating the use of buprenorphine on cocaine use.Drug and alcohol dependence reports · 2026Article
- Cannabidiol Attenuates Heroin Seeking in Male Rats Associated With Normalization of Discrete Neurobiological Signatures Within the Nucleus Accumbens With Subregional Specificity.Biological psychiatry · 2026Article
- An examination of the interaction between the interoceptive and reinforcing properties of morphine: a self-administration study in male and female rats.Psychopharmacology · 2026Article
- Corticostriatal cocaine-seeking ensembles are defined by differing gene expression from sucrose-seeking ensembles using a within-subject dual self-administration and seeking mouse model.Addiction neuroscience · 2025Article
- Overcoming Automatic Behavioral Tendencies in Approach-Avoidance Conflict Decisions.Psychophysiology · 2025Article
- Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex.Pharmacology, biochemistry, and behavior · 2025Article
- Article
- Tobacco Images Choice and its Association With Craving and Dependence in People Who Smoke Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Evaluating a mobile app's effects on depression and anxiety in medication-treated opioid use disorder.Npj mental health research · 2024Article
- The secondary visual cortex mediated the enhancement of associative learning on methamphetamine self-administration behaviors.Psychopharmacology · 2024Article
- Active forgetting and neuropsychiatric diseases.Molecular psychiatry · 2024Review
- An open-source behavior controller for associative learning and memory (B-CALM).Behavior research methods · 2024Article
- Tobacco Images Choice and Its Association with Craving and Dependence in Cigarette Smokers.bioRxiv : the preprint server for biology · 2024Article
- Shisha Consumption and Presence of Cotinine in Saliva Samples among Students in Public Universities in Coastal Kenya.Global health, epidemiology and genomics · 2024Article
- Activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system.Frontiers in molecular neuroscience · 2024Article
- Levodopa reduces consumption of multiple classes of addictive substances in rats.bioRxiv : the preprint server for biology · 2023Article
- Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions.Brain, behavior, and immunity · 2023Review
- Ethanol-paired conditioned stimulus effects on concurrent reinforced responding for ethanol and food.Alcohol (Fayetteville, N.Y.) · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental stimuli are powerful mediators of craving and relapse in substance-abuse disorders. This review examined how animal models have been used to investigate the cognitive mechanisms through which cues are able to affect drug-seeking behaviour. We address how animal models can describe the way drug-associated cues come to facilitate the development and persistence of drug taking, as well as how these cues are critical to the tendency to relapse that characterizes substance-abuse disorders. Drug-associated cues acquire properties of conditioned reinforcement, incentive motivation and discriminative control, which allow them to influence drug-seeking behaviour. Using these models, researchers have been able to investigate the pharmacology subserving the behavioural impact of environmental stimuli, some of which we highlight. Subsequently, we examine whether the impact of drug-associated stimuli can be attenuated via a process of extinction, and how this question is addressed in the laboratory. We discuss how preclinical research has been translated into behavioural therapies targeting substance abuse, as well as highlight potential developments to therapies that might produce more enduring changes in behaviour.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.