ArticleStem cell reports2014
CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Article
- Whence CRIPTO: The Reemergence of an Oncofetal Factor in 'Wounds' That Fail to Heal.International journal of molecular sciences · 2021Review
- CRIPTO antagonist ALK4Breast cancer research : BCR · 2020Article
- Review
- Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response.Journal of molecular and cellular cardiology · 2020Article
- Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development.International journal of molecular sciences · 2019Review
- Identification of myosin II as a cripto binding protein and regulator of cripto function in stem cells and tissue regeneration.Biochemical and biophysical research communications · 2019Article
- Administration of Cripto in GRP78 overexpressed human MSCs enhances stem cell viability and angiogenesis during human MSC transplantation therapy.Cell proliferation · 2018Article
- Cripto Enhances Proliferation and Survival of Mesenchymal Stem Cells by Up-Regulating JAK2/STAT3 Pathway in a GRP78-Dependent Manner.Biomolecules & therapeutics · 2018Article
- Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development.Cell reports · 2018Article
- Cripto stabilizes GRP78 on the cell membrane.Protein science : a publication of the Protein Society · 2018Article
- New Advances and Challenges of Targeting Cancer Stem Cells.Cancer research · 2017Article
- CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer.Oncogene · 2017Article
- Retrospective Proteomic Screening of 100 Breast Cancer Tissues.Proteomes · 2017Article
- GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutantProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.NPJ breast cancer · 2017Article
- Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis.NPJ breast cancer · 2017Article
- Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth.The Journal of biological chemistry · 2016Article
- New insights into the unfolded protein response in stem cells.Oncotarget · 2016Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known about the extracellular signaling factors that govern mammary stem cell behavior. Here, we identify CRIPTO and its cell-surface receptor GRP78 as regulators of stem cell behavior in isolated fetal and adult mammary epithelial cells. We develop a CRIPTO antagonist that promotes differentiation and reduces self-renewal of mammary stem cell-enriched populations cultured ex vivo. By contrast, CRIPTO treatment maintains the stem cell phenotype in these cultures and yields colonies with enhanced mammary gland reconstitution capacity. Surface expression of GRP78 marks CRIPTO-responsive, stem cell-enriched fetal and adult mammary epithelial cells, and deletion of GRP78 from adult mammary epithelial cells blocks their mammary gland reconstitution potential. Together, these findings identify the CRIPTO/GRP78 pathway as a developmentally conserved regulator of fetal and adult mammary stem cell behavior ex vivo, with implications for the stem-like cells found in many cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.