ArticleStem cell reports2014
Do neonatal mouse hearts regenerate following heart apex resection?
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed, 109 citations in OpenAlex.
- Article
- N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic β-Catenin signaling in cardiomyocytes.Nature communications · 2025Article
- Cauterization of the root of the left coronary artery as a straightforward, large and reproducible ischemic injury model in neonatal mice.Lab animal · 2024Review
- Right ventricular cardiomyocyte expansion accompanies cardiac regeneration in newborn mice after large left ventricular infarcts.JCI insight · 2024Article
- The role of periostin in cardiac fibrosis.Heart failure reviews · 2024Review
- Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration.Frontiers in cell and developmental biology · 2024Review
- Ploidy-stratified single cardiomyocyte transcriptomics map Zinc Finger E-Box Binding Homeobox 1 to underly cardiomyocyte proliferation before birth.Basic research in cardiology · 2023Article
- A modified apical resection model with high accuracy and reproducibility in neonatal mouse and rat hearts.NPJ Regenerative medicine · 2023Article
- Investigating the Transient Regenerative Potential of Cardiac Muscle Using a Neonatal Pig Partial Apical Resection Model.Bioengineering (Basel, Switzerland) · 2022Article
- The regenerative capacity of neonatal tissues.Development (Cambridge, England) · 2022Review
- Mechanisms Underlying Cardiomyocyte Development: Can We Exploit Them to Regenerate the Heart?Current cardiology reports · 2021Review
- A Neonatal Mouse Model for Pressure Overload: Myocardial Response Corresponds to Severity.Frontiers in cardiovascular medicine · 2021Article
- Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells.Cardiovascular research · 2021Article
- Cauterization as a Simple Method for Regeneration Studies in the Zebrafish Heart.Journal of cardiovascular development and disease · 2020Article
- Achieving stable myocardial regeneration after apical resection in neonatal mice.Journal of cellular and molecular medicine · 2020Article
- Role of Mononuclear Cardiomyocytes in Cardiac Turnover and Regeneration.Current cardiology reports · 2020Review
- Age-Related Pathways in Cardiac Regeneration: A Role for lncRNAs?Frontiers in physiology · 2020Review
- Model organisms at the heart of regeneration.Disease models & mechanisms · 2019Review
- Proteomics Analysis of Extracellular Matrix Remodeling During Zebrafish Heart Regeneration.Molecular & cellular proteomics : MCP · 2019Article
- Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations.Trends in endocrinology and metabolism: TEM · 2019Review
13 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian heart has generally been considered nonregenerative, but recent progress suggests that neonatal mouse hearts have a genuine capacity to regenerate following apex resection (AR). However, in this study, we performed AR or sham surgery on 400 neonatal mice from inbred and outbred strains and found no evidence of complete regeneration. Ideally, new functional cardiomyocytes, endothelial cells, and vascular smooth muscle cells should be formed in the necrotic area of the damaged heart. Here, damaged hearts were 9.8% shorter and weighed 14% less than sham controls. In addition, the resection border contained a massive fibrotic scar mainly composed of nonmyocytes and collagen disposition. Furthermore, there was a substantial reduction in the number of proliferating cardiomyocytes in AR hearts. Our results thus question the usefulness of the AR model for identifying molecular mechanisms underlying regeneration of the adult heart after damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.