Evidence map›Paper›PMID 24748978›Full record

ArticleBiomedical reports2014

Interleukin-1α -899 (+4845) C→T polymorphism is not associated with aggressive periodontitis susceptibility: A meta-analysis based on 19 case-control studies.

Wan-Fen Wang, Jun Shi, Shao-Juan Chen, Yu-Ming Niu, Xian-Tao Zeng

Abstract read
In one paragraph

Article in Biomedical reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Association of Interleukin-1Genetics research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wan-Fen WangDepartment of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.
Jun ShiDepartment of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.
Shao-Juan ChenDepartment of Stomatology, Shiyan Maternal and Child Health Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.
Yu-Ming NiuDepartment of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China ; Center for Evidence-based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.
Xian-Tao ZengDepartment of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China ; Center for Evidence-based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of published studies investigated the association between interleukin-1α (IL-1α) -899 (+4845) C→T polymorphism and susceptibility to aggressive periodontitis (AgP). However, the results from different studies are controversial. This study was conducted to further investigate the association between IL-1α -899 (+4845) C→T polymorphism and AgP using a meta-analysis. A search was conducted through PubMed up to May 1, 2013 and a total of 19 relevant case-control studies were identified. The results of this meta-analysis demonstrated that IL-1α -899 (+4845) C→T polymorphism is not associated with susceptibility to AgP under allele T vs. C [odds ratio (OR)=1.00, 95% confidence interval (CI): 0.88-1.14, P=0.98; I

Indexed as

aggressive periodontitisinterleukin-1αmeta-analysispolymorphismsusceptibility

Identifiers

PMID24748978
PMCPMC3990208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.