ReviewWorld journal of diabetes2014
Knockout mouse models of insulin signaling: Relevance past and future.
Review in World journal of diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Ubiquitin-Specific Protease 2 (USP2) as a Modulator of Energy Metabolism: A Review of Studies Using Animal and Cellular Models.Biomedicines · 2026Review
- Metabolic Dysregulation in Laminopathies: Implications for Heart Failure and Cardiac Health.Current heart failure reports · 2026Review
- Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats.Scientific reports · 2025Article
- Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection.Cell reports · 2024Article
- Article
- The Regulation of Metabolic Homeostasis by Incretins and the Metabolic Hormones Produced by Pancreatic Islets.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Daily injection of melatonin inhibits insulin resistance induced by chronic mealtime shift.Physiological reports · 2022Article
- Glucose Metabolism in Burns-What Happens?International journal of molecular sciences · 2021Review
- Light control of RTK activity: from technology development to translational research.Chemical science · 2020Review
- Hepatic functional and pathological changes of type 1 diabetic mice in growing and maturation time.Journal of cellular and molecular medicine · 2019Article
- Article
- Sex Differences in Androgen Regulation of Metabolism in Nonhuman Primates.Advances in experimental medicine and biology · 2017Review
- Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling.Diabetologia · 2016Article
- Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome.Molecular metabolism · 2016Review
- Developmental programming: interaction between prenatal BPA exposure and postnatal adiposity on metabolic variables in female sheep.American journal of physiology. Endocrinology and metabolism · 2016Article
- An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus.Journal of diabetes research · 2016Review
- Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22.Journal of diabetes research · 2015Article
- You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes.Nutrition & diabetes · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance is a hallmark of type 2 diabetes. In an effort to understand and treat this condition, researchers have used genetic manipulation of mice to uncover insulin signaling pathways and determine the effects of their perturbation. After decades of research, much has been learned, but the pathophysiology of insulin resistance in human diabetes remains controversial, and treating insulin resistance remains a challenge. This review will discuss limitations of mouse models lacking select insulin signaling molecule genes. In the most influential mouse models, glucose metabolism differs from that of humans at the cellular, organ, and whole-organism levels, and these differences limit the relevance and benefit of the mouse models both in terms of mechanistic investigations and therapeutic development. These differences are due partly to immutable differences in mouse and human biology, and partly to the failure of genetic modifications to produce an accurate model of human diabetes. Several factors often limit the mechanistic insights gained from experimental mice to the particular species and strain, including: developmental effects, unexpected metabolic adjustments, genetic background effects, and technical issues. We conclude that the limitations and weaknesses of genetically modified mouse models of insulin resistance underscore the need for redirection of research efforts toward methods that are more directly relevant to human physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.