ArticleJournal of geriatric cardiology : JGC2014
Aging effects on QT interval: Implications for cardiac safety of antipsychotic drugs.
Article in Journal of geriatric cardiology : JGC, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Surveillance of Corrected QT Interval-Prolonging Medications upon Admission throughout Hospitalization in a Tertiary Care Geriatric Ward.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Article
- Does IV fentanyl, frequently used in emergency departments, change QTBMC anesthesiology · 2024Observational
- A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging.npj aging · 2024Review
- Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations.Drugs & aging · 2024Review
- Differences in circadian variation in QT interval of the ECG in women compared to men.American journal of cardiovascular disease · 2023Article
- Combined Effects of Age and Comorbidities on Electrocardiographic Parameters in a Large Non-Selected Population.Journal of clinical medicine · 2022Article
- Population pharmacokinetic and exposure-response analyses of ivosidenib in patients with IDH1-mutant advanced hematologic malignancies.Clinical and translational science · 2021Article
- QTc Interval Prolongation with Therapies Used to Treat Patients with Parkinson's Disease Psychosis: A Narrative Review.Neuropsychiatric disease and treatment · 2021Review
- Inhaled hydroxychloroquine to improve efficacy and reduce harm in the treatment of COVID-19.Medical hypotheses · 2020Article
- Incidence and outcomes of long QTc in acute medical admissions.International journal of clinical practice · 2018Observational
- Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate.Cardiology research and practice · 2018Article
- Choosing Wisely: Wise Choices in Psychiatry.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2016Article
- Detailed analysis of the impact of age on the QT interval.Journal of geriatric cardiology : JGC · 2016Article
- Antidepressants and antipsychotics classified with torsades de pointes arrhythmia risk and mortality in older adults - a Swedish nationwide study.British journal of clinical pharmacology · 2016Article
- Modulation of the QT interval duration in hypertension with antihypertensive treatment.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Review
- Nomenclature, categorization and usage of formulae to adjust QT interval for heart rate.World journal of cardiology · 2015Review
- Impact of Age and Sex on QT Prolongation in Patients Receiving Psychotropics.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2015Review
- Managing cardiovascular disease risk in patients treated with antipsychotics: a multidisciplinary approach.Journal of multidisciplinary healthcare · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the effect of aging on cardiac toxicity specifically the interaction of age and antipsychotic drugs to alter the QT interval.
methodsTHE MEDLINE DATABASES WERE SEARCHED USING THE OVIDSP PLATFORMS WITH THE SEARCH STRATEGY: "QT interval" or "QT" and "age" or "aging". The entry criteria were: over 10,000 apparently healthy individuals with data on both sexes; QT interval corrected for heart rate (QTc) and an expression of its variance for multiple age decades extending into the older ages.
resultsQTc increased in duration with increasing age. Considering a modest one SD increment in QTc in the normal population, the addition of Chlorpromazine produced a QTc on average greater than 450 ms for ages 70 years and older. Risperidone, that did not on average alter QTc, would be expected to produce a QTc of 450 ms in persons in their mid 70 years under some circumstances. QTc prolongation > 500 ms with antipsychotic drugs is more likely for persons with QTc initially at the 99(th) percentile. It may occur with Haloperidol which does not on average alter QTc.
conclusionsThe range of values for the QT interval in apparently normal older men or women, when combined with the range of expected QT interval changes induced by antipsychotic drugs, can readily be associated with prolonged QTc. Individuals with QTc at the 99(th) percentile may have serious QTc prolongation with antipsychotic drugs even those that are not usually associated with QTc prolongation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.