Evidence map›Paper›PMID 24748808›Full record

ReviewJournal of asthma and allergy2014

Diagnosis and management of eosinophilic asthma: a US perspective.

Hannah H Walford, Taylor A Doherty

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of asthma and allergy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04651777 (Evaluation of Triple Therapy Using Magnetic Resonance Imaging in Asthma), which is not on this map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04651777 phase3active not recruitingnot on this mapstarted 2022, after this paper: background citation

Evaluation of Triple Therapy Using Magnetic Resonance Imaging in Asthma

TypeinterventionalSponsorDr. Grace ParragaRan2022 to 2025Enrolled31ConditionsAsthmaArmsFF/UMEC/VI
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Eosinophil count testing in patients with asthma varies by healthcare provider type in the US: a retrospective study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024
    Article
  14. Review
  15. Article
  16. The Determinants of Eosinophilia in Patients With Severe Asthma.Journal of clinical medicine research · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hannah H WalfordDepartment of Medicine, University of California, La Jolla, CA, USA ; Department of Pediatrics, University of California, La Jolla, CA, USA.
Taylor A DohertyDepartment of Medicine, University of California, La Jolla, CA, USA.
University of California, San Diego · US

Funding

OX40/OX40L interactions in allergen-induced airway inflammation and remodelingK08AI080938 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOHERTY, TAYLOR A · 2010 to 2014
$662k
NIAID NIH HHS K08 AI080938
6 · The paper itself

Abstract

Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell count is the gold standard for identifying eosinophilic inflammation in asthma although several noninvasive biomarkers, including fractional exhaled nitric oxide and periostin, are emerging as potential surrogates. As novel therapies and biologic agents become increasingly available, there is an increased need for specific phenotype-directed treatment strategies. Greater recognition and understanding of the unique immunopathology of this asthma phenotype has important implications for management of the disease and the potential to improve patient outcomes. The present review provides a summary of the clinical features, pathogenesis, diagnosis, and management of eosinophilic asthma.

Indexed as

allergyasthmaeosinophilIL-13IL-4Th2

Identifiers

PMID24748808
PMCPMC3990389
OpenAlexW2007864797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.