ArticleBioinformation2014
Computer Aided Screening of Phytochemicals from Garcinia against the Dengue NS2B/NS3 Protease.
Article in Bioinformation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Identification of Potential Inhibitors Targeting Non-Structural Proteins NS3 and NS5 of Dengue Virus Using Docking and Deep Learning Approaches.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Enzyme Inhibitory Activities of Extracts and Carpachromene from the Stem ofBioMed research international · 2022Article
- Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection.Bioinorganic chemistry and applications · 2022Review
- Chemistry of Protein-Phenolic Interactions Toward the Microbiota and Microbial Infections.Frontiers in nutrition · 2022Review
- Structure-Based Virtual Screening and Biological Evaluation of Peptide Inhibitors for Polo-Box Domain.Molecules (Basel, Switzerland) · 2019Article
- Discovery of a Potent PLK1-PBD Small-Molecule Inhibitor as an Anticancer Drug Candidate through Structure-Based Design.Molecules (Basel, Switzerland) · 2019Article
- Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking and Biological Evaluation for Identification of Potential Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors.Molecules (Basel, Switzerland) · 2019Article
- Structure-Based Pharmacophore Design and Virtual Screening for Novel Tubulin Inhibitors with Potential Anticancer Activity.Molecules (Basel, Switzerland) · 2019Article
- Virucidal activity of Garcinia parvifolia leaf extracts in animal cell culture.BMC complementary and alternative medicine · 2019Article
- Computational screening of medicinal plant phytochemicals to discover potent pan-serotype inhibitors against dengue virus.Scientific reports · 2019Article
- Structure activity relationship (SAR) and quantitative structure activity relationship (QSAR) studies showed plant flavonoids as potential inhibitors of dengue NS2B-NS3 protease.BMC structural biology · 2018Article
- Molecular docking NS4B of DENV 1-4 with known bioactive phyto-chemicals.Bioinformation · 2016Article
- An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever.Combinatorial chemistry & high throughput screening · 2016Article
- Molecular Docking Based Screening of Plant Flavonoids as Dengue NS1 Inhibitors.Bioinformation · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus NS2/NS3 protease because of its ability to cleave viral proteins is considered as an attractive target to screen antiviral agents. Medicinal plants contain a variety of phytochemicals that can be used as drug against different diseases and infections. Therefore, this study was designed to uncover possible phytochemical of different classes (Aromatic, Carbohydrates, Lignin, Saponins, Steroids, Tannins, Terpenoids, Xanthones) that could be used as inhibitors against the NS2B/NS3 protease of DENV. With the help of molecular docking, Garcinia phytochemicals found to be bound deeply inside the active site of DENV NS2B/NS3 protease among all tested phytochemicals and had interactions with catalytic triad (His51, Asp75, Ser135). Thus, it can be concluded from the study that these Gracinia phytochemicals could serve as important inhibitors to inhibit the viral replication inside the host cell. Further in-vitro investigations require confirming their efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.