ArticleToxicology international2014
Ameliorative Effect of Tephrosia Purpurea in Arsenic-induced Nephrotoxicity in Rats.
Article in Toxicology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 24 citations in OpenAlex.
- Nephroprotective effect of magnesium isoglycyrrhizinate against arsenic trioxide-induced acute kidney damage in mice.Experimental and therapeutic medicine · 2022Article
- Association of Metals and Metalloids With Urinary Albumin/Creatinine Ratio: Evidence From a Cross-Sectional Study Among Elderly in Beijing.Frontiers in public health · 2022Article
- Protective effect ofVeterinary world · 2020Article
- High fat diet deteriorates the memory impairment induced by arsenic in mice: a sub chronic in vivo study.Metabolic brain disease · 2019Article
- Administration of zinc against arsenic-induced nephrotoxicity during gestation and lactation in rat model.Journal of nephropathology · 2017Article
- Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB.PloS one · 2015Article
- Effect of Aqueous Extract of Tephrosia purpurea on Cardiovascular Complications and Cataract Associated with Streptozotocin-induced Diabetes in Rats.Indian journal of pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present investigation was conducted to evaluate the nephroprotective activity of Tephrosia purpurea (TPE) against arsenic-induced toxicity. MATERIALS AND
methodsTwenty four number of wistar rats were equally divided into three groups. Sodium arsenite (10 mg/kg) was orally given to group I for 28 days, additionally group II was orally treated with TPE (500 mg/kg), while the control group was kept untreated with neither arsenic nor TPE. Serum biomarker levels, oxidative stress indices and arsenic concentration in kidney were estimated. Histopathology of kidney was also conducted.
resultsGroup II animals show significantly reduced blood urea nitrogen and plasma creatinine, and increased serum albumin level compared to group I. The higher lipid peroxidation with exhausted superoxide dismutase activity and reduced glutathione level were noticed in group I compared to group II. There was no significant difference in arsenic accumulation in kidneys between the two arsenic treated groups, but the histopathology of kidney of group II rats revealed reduced necrosis and intact tubular architecture as compared to group I.
conclusionsTephrosia Purpurea extract has a significant role in protecting the animals from arsenic-induced nephrotoxicity.
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Registered trials
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