Evidence map›Paper›PMID 24748722›Full record

ArticleChemistry of materials : a publication of the American Chemical Society2014

Iron-Loaded Magnetic Nanocapsules for pH-Triggered Drug Release and MRI Imaging.

Hongyu Chen, Dino Sulejmanovic, Thomas Moore, Daniel C Colvin, Bin Qi, O Thompson Mefford, John C Gore, Frank Alexis, Shiou-Jyh Hwu, Jeffrey N Anker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry of materials : a publication of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 85 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hongyu ChenDepartment of Chemistry, Center for Optical Materials Science and Engineering (COMSET), and Environmental Toxicology Program, Clemson University , Clemson, South Carolina 29634, United States.
Dino SulejmanovicDepartment of Chemistry, Center for Optical Materials Science and Engineering (COMSET), and Environmental Toxicology Program, Clemson University , Clemson, South Carolina 29634, United States.
Thomas MooreDepartment of Bioengineering, Clemson University , Clemson, South Carolina 29634, United States.
Daniel C ColvinVanderbilt University Medical Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Bin QiDepartment of Materials Science and Engineering and Center for Optical Materials Science and Engineering (COMSET), Clemson University , Clemson, South Carolina 29634, United States.
O Thompson MeffordDepartment of Materials Science and Engineering and Center for Optical Materials Science and Engineering (COMSET), Clemson University , Clemson, South Carolina 29634, United States.
John C GoreVanderbilt University Medical Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Frank AlexisDepartment of Bioengineering, Clemson University , Clemson, South Carolina 29634, United States.
Shiou-Jyh HwuDepartment of Chemistry, Center for Optical Materials Science and Engineering (COMSET), and Environmental Toxicology Program, Clemson University , Clemson, South Carolina 29634, United States.
Jeffrey N AnkerDepartment of Chemistry, Center for Optical Materials Science and Engineering (COMSET), and Environmental Toxicology Program, Clemson University , Clemson, South Carolina 29634, United States.
Clemson University · USVanderbilt University Medical Center · US

Funding

Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R, VYAVAHARE, NAREN R · 2012 to 2018
$14.9M
UNDERSTANDING AND CONTROLLING TISSUE-SPECIFIC VASCULAR PATTERNINGP20RR021949 · NCRR · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R · 2009 to 2011
$5.2M
NCRR NIH HHS P20 RR021949NIGMS NIH HHS P20 GM103444
6 · The paper itself

Abstract

Magnetic nanocapsules were synthesized for controlled drug release, magnetically assisted delivery, and MRI imaging. These magnetic nanocapsules, consisting of a stable iron nanocore and a mesoporous silica shell, were synthesized by controlled encapsulation of ellipsoidal hematite in silica, partial etching of the hematite core in acid, and reduction of the core by hydrogen. The iron core provided a high saturation magnetization and was stable against oxidation for at least 6 months in air and 1 month in aqueous solution. The hollow space between the iron core and mesoporous silica shell was used to load anticancer drug and a T

Identifiers

PMID24748722
PMCPMC3988683
OpenAlexW2088075975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.