Evidence map›Paper›PMID 24748637›Full record

Trial reportArchives of disease in childhood2014

Vitamin D treatment in calcium-deficiency rickets: a randomised controlled trial.

Tom D Thacher, Philip R Fischer, John M Pettifor

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of disease in childhood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00949832 (Vitamin D and Genetics in Nutritional Rickets), which is not on this map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00949832 phase4completednot on this map

Vitamin D and Genetics in Nutritional Rickets

TypeinterventionalSponsorMayo ClinicRan2004 to 2007Enrolled109ConditionsNutritional RicketsArmsVitamin D + Calcium, Calcium, Vitamin D2, Vitamin D3
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.The Journal of clinical endocrinology and metabolism · 2016
    Review
  17. Article
  18. Article
  19. [In time: vitamin D deficiency: who needs supplementation?].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Tom D ThacherDepartment of Family Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Philip R FischerDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
John M PettiforMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.
Mayo Clinic · USUniversity of the Witwatersrand · ZA

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
NCATS NIH HHS UL1 TR000135NCRR NIH HHS 1 UL1 RR024150NCRR NIH HHS UL1 RR024150
6 · The paper itself

Abstract

objectiveTo determine whether children with calcium-deficiency rickets have a better response to treatment with vitamin D and calcium than with calcium alone.

designRandomised controlled trial.

settingJos University Teaching Hospital, Jos, Nigeria. POPULATION: Nigerian children with active rickets treated with calcium carbonate as limestone (approximately 938 mg elemental calcium twice daily) were, in addition, randomised to receive either oral vitamin D2 50,000 IU (Ca+D, n=44) or placebo (Ca, n=28) monthly for 24 weeks.

main outcome measureAchievement of a 10-point radiographic severity score ≤1.5 and serum alkaline phosphatase ≤350 U/L.

resultsThe median (range) age of enrolled children was 46 (15-102) months, and baseline characteristics were similar in the two groups. Mean (±SD) 25-hydroxyvitamin D (25(OH)D) was 30.2±13.2 nmol/L at baseline, and 29 (43%) had values <30 nmol/L. Baseline alkaline phosphatase and radiographic scores were unrelated to vitamin D status. Of the 68 children (94% of original cohort) who completed 24 weeks of treatment, 29 (67%) in the Ca+D group and 11 (44%) in the Ca group achieved the primary outcome (p=0.06). Baseline 25(OH)D did not alter treatment group effects (p=0.99 for interaction). At the end of 24 weeks, 25(OH)D values were 55.4±17.0 nmol/L and 37.9±20.0 nmol/L in the Ca+D and Ca groups, respectively, (p<0.001). In the Ca+D and Ca groups, the final 25(OH)D concentration was greater in those who achieved the primary outcome (56.4±17.2 nmol/L) than in those who did not (37.7±18.5 nmol/L, p<0.001).

conclusionsIn children with calcium-deficiency rickets, there is a trend for vitamin D to improve the response to treatment with calcium carbonate as limestone, independent of baseline 25(OH)D concentrations. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT00949832.

Indexed as

Absorptiometry, PhotonAlkaline PhosphataseCalciumChildChild, PreschoolErgocalciferolsFemaleHumansInfantMaleNigeriaRicketsTreatment OutcomeVitamin D25-hydroxyvitamin DAlkaline PhosphataseCalciumErgocalciferolsVitamin D

Identifiers

PMID24748637
PMCPMC4145444
OpenAlexW2097739372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.