ArticleNeuroradiology2014
Regional apparent diffusion coefficient values in 3rd trimester fetal brain.
Article in Neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Association between fetal brain diffusion-weighted imaging and postnatal neurodevelopmental outcome after prenatal myelomeningocele repair.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Evaluation of brain microstructure changes in surviving fetus of monochorionic twin pregnancies with single intrauterine fetal death using diffusion weighted imaging: a MRI-based cohort study.BMC medical imaging · 2025Article
- Intravoxel incoherent motion MRI to assess feto-placental diffusion and perfusion properties in small fetuses.La Radiologia medica · 2025Article
- Measurement of apparent diffusion coefficient (ADC) in fetal organs and placenta using 3 Tesla magnetic resonance imaging (MRI) across gestational ages.Scientific reports · 2024Observational
- Establishing and Comparing the Normal apparent Diffusion Coefficient Values of Fetal Organs and Placenta Using 1.5 Tesla and 3.0 T MRI at Various Gestational Age.Ethiopian journal of health sciences · 2023Observational
- ADC values as a biomarker of fetal brain maturation.Radiology and oncology · 2023Article
- 3.0 Tesla normative diffusivity in 3rd trimester fetal brain.Neuroradiology · 2022Article
- Brain fetal magnetic resonance imaging to evaluate maturation of normal white matter during the third trimester of pregnancy.Pediatric radiology · 2021Article
- MRI signs of intrauterine fetal demise.Abdominal radiology (New York) · 2021Review
- The prevalence of brain lesions after in utero surgery for twin-to-twin transfusion syndrome on third-trimester MRI: a retrospective cohort study.European radiology · 2021Article
- Lateral ventricular volume and calcarine sulcus depth: a fetal MRI analysis of mild ventriculomegaly: A STROBE compliant article.Medicine · 2020Article
- Apparent Diffusion Coefficient Levels and Neurodevelopmental Outcome in Fetuses with Brain MR Imaging White Matter Hyperintense Signal.AJNR. American journal of neuroradiology · 2018Article
- Apparent Diffusion Coefficient Value Changes and Clinical Correlation in 90 Cases of Cytomegalovirus-Infected Fetuses with Unremarkable Fetal MRI Results.AJNR. American journal of neuroradiology · 2017Article
- Findings and differential diagnosis of fetal intracranial haemorrhage and fetal ischaemic brain injury: what is the role of fetal MRI?The British journal of radiology · 2017Review
- Region-specific changes in brain diffusivity in fetal isolated mild ventriculomegaly.European radiology · 2016Article
- Fetal MRI: A Technical Update with Educational Aspirations.Concepts in magnetic resonance. Part A, Bridging education and research · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionApparent diffusion coefficient (ADC) values in the developing fetus can be used in the diagnosis and prognosis of prenatal brain pathologies. To this end, we measured regional ADC in a relatively large cohort of normal fetal brains in utero.
methodsDiffusion-weighted imaging (DWI) was performed in 48 non-sedated 3rd trimester fetuses with normal structural MR imaging results. ADC was measured in white matter (frontal, parietal, temporal, and occipital lobes), basal ganglia, thalamus, pons, and cerebellum. Regional ADC values were compared by one-way ANOVA with gestational age as covariate. Regression analysis was used to examine gestational age-related changes in regional ADC. Four other cases of CMV infection were also examined.
resultsMedian gestational age was 32 weeks (range, 26-33 weeks). There was a highly significant effect of region on ADC, whereby ADC values were highest in white matter, with significantly lower values in basal ganglia and cerebellum and the lowest values in thalamus and pons. ADC did not significantly change with gestational age in any of the regions tested. In the four cases with fetal CMV infection, ADC value was associated with a global decrease.
conclusionADC values in normal fetal brain are relatively stable during the third trimester, show consistent regional variation, and can make an important contribution to the early diagnosis and possibly prognosis of fetal brain pathologies.
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