Evidence map›Paper›PMID 24748446›Full record

ArticleAnalytical and bioanalytical chemistry2014

A biocatalytic cascade with several output signals--towards biosensors with different levels of confidence.

Nataliia Guz, Jan Halámek, James F Rusling, Evgeny Katz

Abstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nataliia GuzDepartment of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, 13699-5810, USA.
Jan Halámek
James F Rusling
Evgeny Katz

Funding

Protein Biosensor Arrays Based on NanomaterialsR01EB014586 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI RUSLING, JAMES F. · 2011 to 2014
$1.4M
NIBIB NIH HHS EB014586NIBIB NIH HHS R01 EB014586
6 · The paper itself

Abstract

The biocatalytic cascade based on enzyme-catalyzed reactions activated by several biomolecular input signals and producing output signal after each reaction step was developed as an example of a logically reversible information processing system. The model system was designed to mimic the operation of concatenated AND logic gates with optically readable output signals generated at each step of the logic operation. Implications include concurrent bioanalyses and data interpretation for medical diagnostics.

Indexed as

Biosensing TechniquesAdenosine DiphosphateAdenosine TriphosphateBiological AssayBiomarkersCatalysisChemistry Techniques, AnalyticalDiagnostic Tests, RoutineGlyceric AcidsHumansL-Lactate DehydrogenaseMixed Function OxygenasesNADOptics and PhotonicsOxygenPhosphoenolpyruvate2-phosphoglycerateAdenosine DiphosphateAdenosine TriphosphateBiomarkersGlyceric Acidslactate 2-monooxygenaseL-Lactate DehydrogenaseMixed Function OxygenasesNADOxygenPhosphoenolpyruvatePhosphopyruvate Hydratase

Identifiers

PMID24748446
PMCPMC4072206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.