ArticlePloS one2014
Soluble extract from Moringa oleifera leaves with a new anticancer activity.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 270 citations in OpenAlex.
- Biological properties ofF1000Research · 2024Pooled it
- A Comparison of the Antibacterial Effects of Moringa Oleifera and Eucalyptus As Intracanal Irrigants on Enterococcus Faecalis: An in Vitro Study : Short title: Antimicrobial Efficacy of Herbal Products against E.faecalis.Galen medical journal · 2026Article
- Review
- Anticancer effect of Moringa oleifera in oral squamous cell carcinoma: a systematic review.Discover oncology · 2024Review
- Photoactive metabolite mediated photodynamic therapy of Rhabdomyosarcoma cell lines using medicinal plants and Doxorubicin co-treatments.BMC complementary medicine and therapies · 2024Article
- Medicinal utilization and nutritional properties of drumstick (Food science & nutrition · 2024Review
- A comprehensive review of the phytochemicals, health benefits, pharmacological safety and medicinal prospects ofHeliyon · 2024Review
- Article
- Review
- Nigerian medicinal plants with potential anticancer activity-a review.Exploration of targeted anti-tumor therapy · 2024Review
- Hypoglycemic Assessment of Aqueous Leaf Extract ofBiochemistry research international · 2024Article
- Integrated Action of Rhizobacteria withPlants (Basel, Switzerland) · 2023Article
- Review
- Natural products targeting inflammation-related metabolic disorders: A comprehensive review.Heliyon · 2023Review
- Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts ofOxidative medicine and cellular longevity · 2023Article
- A Comparative Evaluation of Antibacterial Efficacy ofInternational journal of dentistry · 2023Article
- Phycocyanin Protects against High Glucose High Fat Diet Induced Diabetes in Mice and Participates in AKT and AMPK Signaling.Foods (Basel, Switzerland) · 2022Article
- A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers.Cancers · 2022Review
- Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols fromMolecules (Basel, Switzerland) · 2022Article
- Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats.Asian Pacific journal of cancer prevention : APJCP · 2022Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moringa oleifera has been regarded as a food substance since ancient times and has also been used as a treatment for many diseases. Recently, various therapeutic effects of M. oleifera such as antimicrobial, anticancer, anti-inflammatory, antidiabetic, and antioxidant effects have been investigated; however, most of these studies described only simple biological phenomena and their chemical compositions. Due to the increasing attention on natural products, such as those from plants, and the advantages of oral administration of anticancer drugs, soluble extracts from M. oleifera leaves (MOL) have been prepared and their potential as new anticancer drug candidates has been assessed in this study. Here, the soluble cold Distilled Water extract (4°C; concentration, 300 µg/mL) from MOL greatly induced apoptosis, inhibited tumor cell growth, and lowered the level of internal reactive oxygen species (ROS) in human lung cancer cells as well as other several types of cancer cells, suggesting that the treatment of cancer cells with MOL significantly reduced cancer cell proliferation and invasion. Moreover, over 90% of the genes tested were unexpectedly downregulated more than 2-fold, while just below 1% of the genes were upregulated more than 2-fold in MOL extract-treated cells, when compared with nontreated cells. Since severe dose-dependent rRNA degradation was observed, the abnormal downregulation of numerous genes was considered to be attributable to abnormal RNA formation caused by treatment with MOL extracts. Additionally, the MOL extract showed greater cytotoxicity for tumor cells than for normal cells, strongly suggesting that it could potentially be an ideal anticancer therapeutic candidate specific to cancer cells. These results suggest the potential therapeutic implications of the soluble extract from MOL in the treatment of various types of cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.