ReviewMetabolic brain disease2015
Role of social factors on cell death, cerebral plasticity and recovery after stroke.
Review in Metabolic brain disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Effects of Objective and Perceived Social Isolation on Cardiovascular and Brain Health: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2022Pooled it
- Lesion loci of impaired affective prosody: A systematic review of evidence from stroke.Brain and cognition · 2021Pooled it
- Feeling lonely and dissatisfied - understanding social network functioning in stroke survivors.BMC psychology · 2024Article
- [Loneliness as health risk: a narrative review].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2024Review
- Effects of visual arts-based interventions on physical and psychosocial outcomes of people with stroke: A systematic review and meta-analysis.International journal of nursing studies advances · 2023Review
- Post-Stroke Brain Health Monitoring and Optimization: A Narrative Review.Journal of clinical medicine · 2023Review
- Association between Living Conditions and the Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults.Internal medicine (Tokyo, Japan) · 2023Article
- Leveraging Social Networks for the Assessment and Management of Neurological Patients.Seminars in neurology · 2022Review
- Noncoding RNA crosstalk in brain health and diseases.Neurochemistry international · 2021Review
- Post-Stroke Social Isolation Reduces Cell Proliferation in the Dentate Gyrus and Alters miRNA Profiles in the Aged Female Mice Brain.International journal of molecular sciences · 2020Article
- Social Network Mapping and Functional Recovery Within 6 Months of Ischemic Stroke.Neurorehabilitation and neural repair · 2019Article
- Participation and autonomy five years after stroke: A longitudinal observational study.PloS one · 2019Observational
- Social influences on microglial reactivity and neuronal damage after cardiac arrest/cardiopulmonary resuscitation.Physiology & behavior · 2018Article
- Cell Therapy in Stroke-Cautious Steps Towards a Clinical Treatment.Translational stroke research · 2018Review
- Association between marriage and outcomes in patients with acute ischemic stroke.Journal of neurology · 2018Article
- Assessed and Emerging Biomarkers in Stroke and Training-Mediated Stroke Recovery: State of the Art.Neural plasticity · 2017Review
- Social networks and neurological illness.Nature reviews. Neurology · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Stroke is a serious global health care problem. It is now is the fourth leading cause of death and the primary cause of adult disability in the United States. Substantial evidence from both experimental and clinical studies has demonstrated that social isolation (SI) can increase stroke incidence and impair recovery. Epidemiological studies demonstrate that an increasing number of patients are living alone, and as the aging population increases, loneliness will only increase in prevalence. SI is increasingly identified as an independent risk factor for all-cause mortality. In contrast, individuals with high levels of social support exhibit more rapid and extensive functional and cognitive recovery after a wide variety of pathological insults, including stroke. Clinical data suggests that SI is an important risk factor for increased mortality and delayed functional recovery following ischemic stroke. Attesting to the importance of mortality and behavioral factors in stroke outcome is that these same effects can be reproduced in animal models of experimental stroke. This has allowed researchers to identify several mechanistic changes that occur with affiliative interactions. These include decreased systemic inflammation, elaboration of growth factors including brain derived neurotropic factor (BDNF), enhanced neurogenesis, and improved neuroimmune responsiveness in group housed animals. These may mediate the beneficial effects of social interaction on improving stroke recovery and reducing neuronal death. In this review we provide an overview of the effects of SI on ischemic injury and recovery and discuss their clinical and therapeutic implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.