ArticleEndocrine2014
The cholinergic system of the preoptic-anterior hypothalamic areas regulates the ovarian follicular population in an asymmetric way.
Article in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- The Left-Right Side-Specific Neuroendocrine Signaling from Injured Brain: An Organizational Principle.Function (Oxford, England) · 2024Article
- Functional Aspects of Hypothalamic Asymmetry.Brain sciences · 2020Review
- Clock control of mammalian reproductive cycles: Looking beyond the pre-ovulatory surge of gonadotropins.Reviews in endocrine & metabolic disorders · 2020Review
- Muscarinic Receptors Types 1 and 2 in the Preoptic-Anterior Hypothalamic Areas Regulate Ovulation Unequally in the Rat Oestrous Cycle.International journal of endocrinology · 2017Article
- The participation of the muscarinic receptors in the preoptic-anterior hypothalamic areas in the regulation of ovulation depends on the ovary.Reproductive biology and endocrinology : RB&E · 2016Article
- Unilaterally blocking the muscarinic receptors in the suprachiasmatic nucleus in proestrus rats prevents pre-ovulatory LH secretion and ovulation.Reproductive biology and endocrinology : RB&E · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atropine implants in the preoptic-anterior hypothalamic areas (POA-AHA) block ovulation. The blocking effects depend on the side of POA-AHA and the day of the estrous cycle in which the implants are inserted. Since ovulation is the result of the growth and differentiation of ovarian follicles, the purpose of this study was to analyze the changes in follicular and atresia population in the ovaries of non-ovulating rats resulting from the unilateral atropine implants in the POA-AHA. Groups of cyclic rats were implanted with atropine or cholesterol (sham treatment group) in the left (diestrus-1, diestrus-2) or the right side (estrus, diestrus-1) of the POA-AHA. The animals were sacrificed on the expected proestrus or estrus day, and the follicular population was counted and the follicles measured in both ovaries. Atropine implants inserted in the left POA-AHA on diestrus-2 resulted in lower follicular growth and atresia in the ipsilateral ovary (left one). No apparent effects were observed in the right ovary. Atropine implants inserted in the right POA-AHA on estrus day resulted in fewer numbers of small follicles in the ipsilateral ovary (right) and a greater number of pre-ovulatory ones. Present results suggest that acetylcholine, via muscarinic receptors of the POA-AHA, regulates ovarian follicular fate in an asymmetric way, and that its actions fluctuate during the estrous cycle. In addition, each ovary seems to respond differently to the POA-AHA's muscarinic signal surge on estrus and diestrus-2 days.
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