ArticlePloS one2014
In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Risk of Benign Paroxysmal Positional Vertigo Modified by Diuretics-A Population-Level Case-Control Study.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- The Role of Intrinsically Disordered Proteins in Liquid-Liquid Phase Separation during Calcium Carbonate Biomineralization.Biomolecules · 2022Review
- Advances in otolith-related protein research.Frontiers in neuroscience · 2022Review
- High Serum Levels of Otolin-1 in Patients With Benign Paroxysmal Positional Vertigo Predict Recurrence.Frontiers in neurology · 2022Article
- Natural Mutations Affect Structure and Function of gC1q Domain of Otolin-1.International journal of molecular sciences · 2021Article
- Molecular mechanism of calcium induced trimerization of C1q-like domain of otolin-1 from human and zebrafish.Scientific reports · 2021Article
- Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes.Frontiers in neurology · 2020Article
- Zebrafish otolith biomineralization requires polyketide synthase.Mechanisms of development · 2019Article
- Chiral switching in biomineral suprastructures induced by homochiral l-amino acid.Science advances · 2018Article
- Assessment of Bone Metabolism in Male Patients With Benign Paroxysmal Positional Vertigo.Frontiers in neurology · 2018Article
- Otoconia and otolithic membrane fragments within the posterior semicircular canal in benign paroxysmal positional vertigo.The Laryngoscope · 2017Article
- Mechanisms of otoconia and otolith development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Effect of Otoconial Proteins Fetuin A, Osteopontin, and Otoconin 90 on the Nucleation and Growth of Calcite.Crystal growth & design · 2015Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Otoconia are formed embryonically and are instrumental in detecting linear acceleration and gravity. Degeneration and fragmentation of otoconia in elderly patients leads to imbalance resulting in higher frequency of falls that are positively correlated with the incidence of bone fractures and death. In this work we investigate the roles otoconial proteins Otolin-1 and Otoconin 90 (OC90) perform in the formation of otoconia. We demonstrate by rotary shadowing and atomic force microscopy (AFM) experiments that Otolin-1 forms homomeric protein complexes and self-assembled networks supporting the hypothesis that Otolin-1 serves as a scaffold protein of otoconia. Our calcium carbonate crystal growth data demonstrate that Otolin-1 and OC90 modulate in vitro calcite crystal morphology but neither protein is sufficient to produce the shape of otoconia. Coadministration of these proteins produces synergistic effects on crystal morphology that contribute to morphology resembling otoconia.
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