ArticlePloS one2014
Wild-type measles viruses with non-standard genome lengths.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Characteristics and Genomic Diversity of Measles Virus From Measles Cases With Known Vaccination Status in Shanghai, China.Frontiers in medicine · 2022Article
- Population Variability Generated during Rescue Process and Passaging of Recombinant Mumps Viruses.Viruses · 2021Article
- Molecular epidemiology of peste des petits ruminants virus emergence in critically endangered Mongolian saiga antelope and other wild ungulates.Virus evolution · 2021Article
- Near-Complete Genome Sequence of a Swine Norovirus GII.11 Strain Detected in Japan in 2018.Microbiology resource announcements · 2020Article
- Full genome sequencing of archived wild type and vaccine rinderpest virus isolates prior to their destruction.Scientific reports · 2020Article
- Analysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the Brain.Journal of virology · 2019Article
- Complete Genome Sequences of Six Measles Virus Strains.Genome announcements · 2018Article
- Article
- Complete Genome Sequences of Mumps and Measles Virus Isolates from Three States in the United States.Genome announcements · 2017Article
- Common position of indels that cause deviations from canonical genome organization in different measles virus strains.Virology journal · 2016Article
- Review
- Genome characterization and phylogenetic analysis of a lineage IV peste des petits ruminants virus in southern China.Virus genes · 2015Article
- Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins.Cell reports · 2015Article
- Long-term transmission of measles virus in Central and continental Western Europe.Virus genes · 2015Review
- Singapore's efforts to achieve measles elimination in 2018.Western Pacific surveillance and response journal : WPSARArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The length of the single stranded, negative sense RNA genome of measles virus (MeV) is highly conserved at 15,894 nucleotides (nt). MeVs can be grouped into 24 genotypes based on the highly variable 450 nucleotides coding for the carboxyl-terminus of the nucleocapsid protein (N-450). Here, we report the genomic sequences of 2 wild-type viral isolates of genotype D4 with genome lengths of 15,900 nt. Both genomes had a 7 nt insertion in the 3' untranslated region (UTR) of the matrix (M) gene and a 1 nt deletion in the 5' UTR of the fusion (F) gene. The net gain of 6 nt complies with the rule-of-six required for replication competency of the genomes of morbilliviruses. The insertions and deletion (indels) were confirmed in a patient sample that was the source of one of the viral isolates. The positions of the indels were identical in both viral isolates, even though epidemiological data and the 3 nt differences in N-450 between the two genomes suggested that the viruses represented separate chains of transmission. Identical indels were found in the M-F intergenic regions of 14 additional genotype D4 viral isolates that were imported into the US during 2007-2010. Viral isolates with and without indels produced plaques of similar size and replicated efficiently in A549/hSLAM and Vero/hSLAM cells. This is the first report of wild-type MeVs with genome lengths other than 15,894 nt and demonstrates that the length of the M-F UTR of wild-type MeVs is flexible.
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