ArticleJournal of visualized experiments : JoVE2014
Facial transplants in Xenopus laevis embryos.
Article in Journal of visualized experiments : JoVE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Jak2 and Jaw Muscles Are Required for Buccopharyngeal Membrane Perforation during Mouth Development.Journal of developmental biology · 2023Article
- The Many Faces ofFrontiers in physiology · 2019Article
- The Zahn drawings: new illustrations ofDevelopment (Cambridge, England) · 2017Article
- Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling.Cell reports · 2016Article
- The role of folate metabolism in orofacial development and clefting.Developmental biology · 2015Article
- Hedgehog activity controls opening of the primary mouth.Developmental biology · 2014Article
- The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling.Cell reports · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Craniofacial birth defects occur in 1 out of every 700 live births, but etiology is rarely known due to limited understanding of craniofacial development. To identify where signaling pathways and tissues act during patterning of the developing face, a 'face transplant' technique has been developed in embryos of the frog Xenopus laevis. A region of presumptive facial tissue (the "Extreme Anterior Domain" (EAD)) is removed from a donor embryo at tailbud stage, and transplanted to a host embryo of the same stage, from which the equivalent region has been removed. This can be used to generate a chimeric face where the host or donor tissue has a loss or gain of function in a gene, and/or includes a lineage label. After healing, the outcome of development is monitored, and indicates roles of the signaling pathway within the donor or surrounding host tissues. Xenopus is a valuable model for face development, as the facial region is large and readily accessible for micromanipulation. Many embryos can be assayed, over a short time period since development occurs rapidly. Findings in the frog are relevant to human development, since craniofacial processes appear conserved between Xenopus and mammals.
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Registered trials
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