ReviewMedical science monitor : international medical journal of experimental and clinical research2014
The association of Restless Legs Syndrome with hypertension and cardiovascular disease.
Review in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Sympathetic Activation and Sleep-Related Movements: Integrating Autonomic, Dopaminergic, and Iron Deficiency Mechanisms.Brain sciences · 2026Review
- Case Series and Literature Review on Phenotypic Variants of Restless Legs Syndrome (RLS): A Unique Phase of Typical RLS?Nature and science of sleep · 2025Article
- Evaluation of potential cardiovascular risk protein biomarkers in high severity restless legs syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Antibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric Disorders.Medical science monitor : international medical journal of experimental and clinical research · 2017Review
- Restless Legs Syndrome in Patients with Hypertension and Diabetes Mellitus.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review).International journal of molecular medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless Legs Syndrome (RLS), is a sensory-motor neurological disorder that appears to be surprisingly common in the community. Periodic limb movements in sleep are typically encountered in more than 80% of RLS patients and comprise involuntary muscular jerks in the lower limbs, such as flexion of the knees or ankles. Iron deficiency and dopaminergic neuronal dysfunction in the central nervous system are currently thought to be the likely pathophysiological culprits. There is evidence linking RLS to hypertension and cardiovascular disease. This short review will first present a synopsis of epidemiological, clinical and pathophysiological data concerning the syndrome, and then information on the possible links between RLS and cardiovascular disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.