ArticleMedical science monitor : international medical journal of experimental and clinical research2014
Calreticulin contributes to C1q-dependent recruitment of microglia in the leech Hirudo medicinalis following a CNS injury.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- C1q-CD44 interactions regulate microglial phagocytosis, proliferation, and migration.Journal of neuroinflammation · 2026Article
- C1q-CD44 interactions regulate microglial phagocytosis, proliferation, and migration.Research square · 2025Article
- Evolution of Microglia.Advances in neurobiology · 2024Article
- A Comparative Biology of Microglia Across Species.Frontiers in cell and developmental biology · 2021Review
- Isolation of microglia-derived extracellular vesicles: towards miRNA signatures and neuroprotection.Journal of nanobiotechnology · 2019Article
- ALK4/5-dependent TGF-β signaling contributes to the crosstalk between neurons and microglia following axonal lesion.Scientific reports · 2019Article
- Proteomic characterisation of leech microglia extracellular vesicles (EVs): comparison between differential ultracentrifugation and Optiprep™ density gradient isolation.Journal of extracellular vesicles · 2019Article
- Medicinal Leech CNS as a Model for Exosome Studies in the Crosstalk between Microglia and Neurons.International journal of molecular sciences · 2018Article
- HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma.Oncotarget · 2017Article
- Calreticulin Promotes Proliferation and Migration But Inhibits Apoptosis in Schwann Cells.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function.Stem cells international · 2016Review
- Nao-Xue-Shu Oral Liquid Improves Aphasia of Mixed Stroke.Evidence-based complementary and alternative medicine : eCAM · 2015Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe medicinal leech is considered as a complementary and appropriate model to study immune functions in the central nervous system (CNS). In a context in which an injured leech's CNS can naturally restore normal synaptic connections, the accumulation of microglia (immune cells of the CNS that are exclusively resident in leeches) has been shown to be essential at the lesion to engage the axonal sprouting. HmC1q (Hm for Hirudo medicinalis) possesses chemotactic properties that are important in the microglial cell recruitment by recognizing at least a C1q binding protein (HmC1qBP alias gC1qR). MATERIAL AND
methodsRecombinant forms of C1q were used in affinity purification and in vitro chemotaxis assays. Anti-calreticulin antibodies were used to neutralize C1q-mediated chemotaxis and locate the production of calreticulin in leech CNS.
resultsA newly characterized leech calreticulin (HmCalR) has been shown to interact with C1q and participate to the HmC1q-dependent microglia accumulation. HmCalR, which has been detected in only some microglial cells, is consequently a second binding protein for HmC1q, allowing the chemoattraction of resident microglia in the nerve repair process.
conclusionsThese data give new insight into calreticulin/C1q interaction in an immune function of neuroprotection, suggesting another molecular target to use in investigation of microglia reactivity in a model of CNS injury.
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