SynthesisBMJ open2014
Dietary fatty acids in the secondary prevention of coronary heart disease: a systematic review, meta-analysis and meta-regression.
Synthesis in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of oils and solid fats on blood lipids: a systematic review and network meta-analysis.Journal of lipid research · 2018Pooled it
- The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials.Nutrition journal · 2017Pooled it
- Pooled it
- Postprandial Lipemic Responses to Various Sources of Saturated and Monounsaturated Fat in Adults.Nutrients · 2019Trial
- Trial
- Nutritional Evaluation of Traditional Portuguese Recipes from Three Different Regions: A Contribution to Food Composition Databases.Nutrients · 2026Article
- Review
- Effects of high-oleic dietary interventions on cardiometabolic outcomes in adults: a GRADE-based systematic review and meta-analysis of randomized controlled trials.Diabetology & metabolic syndrome · 2026Review
- The Intersection of Genetic Factors, Aberrant Nutrient Metabolism and Oxidative Stress in the Progression of Cardiometabolic Disease.Antioxidants (Basel, Switzerland) · 2024Review
- Saturated fat, the estimated absolute risk and certainty of risk for mortality and major cancer and cardiometabolic outcomes: an overview of systematic reviews.Systematic reviews · 2023Review
- Associations between saturated fat intake and other dietary macronutrients and incident hypertension in a prospective study of French women.European journal of nutrition · 2023Article
- Article
- Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention.TheScientificWorldJournal · 2023Review
- Review
- The associations of circulating common and uncommon polyunsaturated fatty acids and modification effects on dietary quality with all-cause and disease-specific mortality in NHANES 2003-2004 and 2011-2012.Annals of medicine · 2021Article
- Review
- The effects of fat consumption on low-density lipoprotein particle size in healthy individuals: a narrative review.Lipids in health and disease · 2021Review
- Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants.Scientific reports · 2021Article
- Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway.Molecular medicine reports · 2020Article
- Plant-sourced and animal-sourced monounsaturated fatty acid intakes in relation to mortality: a prospective nationwide cohort study.European journal of nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious systematic reviews were not restricted to either primary or secondary prevention trials, this study aimed to investigate the effects of reduced and/or modified fat diets and dietary fatty acids on all-cause mortality, cardiovascular mortality and cardiovascular events in participants with established coronary heart disease.
designSystematic review, meta-analysis and univariate/multivariate meta-regression. ELIGIBILITY AND CRITERIA FOR SELECTING STUDIES: Electronic searches for randomised controlled trials comparing reduced/modified fat diets versus control diets were performed in MEDLINE, EMBASE and the Cochrane Library. DATA EXTRACTION: Pooled effects were calculated using an inverse-variance random effect meta-analysis. Random effects univariate and multivariate meta-regressions were performed including changes in all types of dietary fatty acids.
resultsOverall, 12 studies enrolling 7150 participants were included in the present systematic review. No significant risk reduction could be observed considering all-cause mortality (relative risk (RR) 0.92, p=0.60; I(2)=59%) and cardiovascular mortality (RR 0.96, p=0.84; I(2)=69%), combined cardiovascular events (RR 0.85, p=0.30; I(2)=75%) and myocardial infarction (RR 0.76, p=0.13; I(2)=55%) comparing modified fat diets versus control diets. This results could be confirmed for the reduced fat versus control diets (RR 0.79, p=0.47; I(2)=0%), (RR 0.93, p=0.66; I(2)=0%), (RR 0.93, p=0.71; I(2)=57%) and (RR 1.18, p=0.26; I(2)=18%). The multivariate and univariate model showed no significant associations between the independent variables and the changes from saturated fat, monounsaturated fat, polyunsaturated fat and linoleic acid. Sensitivity analyses did not reveal a significant risk reduction for any outcome parameter when polyunsaturated fat was increased in exchange for saturated fat.
conclusionsThe present systematic review provides no evidence (moderate quality evidence) for the beneficial effects of reduced/modified fat diets in the secondary prevention of coronary heart disease. Recommending higher intakes of polyunsaturated fatty acids in replacement of saturated fatty acids was not associated with risk reduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.