ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
FOXO3 and related transcription factors in development, aging, and exceptional longevity.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Glucose and Lipid Metabolic Mechanisms in Vascular Aging and Related Therapeutic Strategies.Reviews in cardiovascular medicine · 2026Review
- Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling.Protein & cell · 2024Article
- Comparative genome analysis of three euplotid protists provides insights into the evolution of nanochromosomes in unicellular eukaryotic organisms.Marine life science & technology · 2023Article
- ERBB2-PTGS2 axis promotes intervertebral disc degeneration by regulating senescence of nucleus pulposus cells.BMC musculoskeletal disorders · 2023Article
- Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration.BMC musculoskeletal disorders · 2022Article
- Integrative analysis of microRNA-320a-related genes in osteoarthritis cartilage.Frontiers in surgery · 2022Article
- Down-Regulation of microRNA-30d Alleviates Intervertebral Disc Degeneration Through the Promotion of FOXO3 and Suppression of CXCL10.Calcified tissue international · 2021Article
- The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.Journal of translational medicine · 2020Article
- FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome-Wide Occupancy Profiling Reveals Critical Roles of FoxO1 in Regulating Extracellular Matrix and Circadian Rhythm Genes in Human Chondrocytes.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Genetics of extreme human longevity to guide drug discovery for healthy ageing.Nature metabolism · 2020Review
- MEG3 promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-361-5p/FOXO1 axis.BMC medical genomics · 2019Article
- Development of the axial skeleton and intervertebral disc.Current topics in developmental biology · 2019Review
- FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.Aging cell · 2018Article
- Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.Blood · 2018Article
- FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.Science translational medicine · 2018Article
- Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- GH and ageing: Pitfalls and new insights.Best practice & research. Clinical endocrinology & metabolism · 2017Review
- FUS-linked essential tremor associated with motor dysfunction in Drosophila.Human genetics · 2016Article
- Healthspan and longevity can be extended by suppression of growth hormone signaling.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In June 2013, a workshop was convened in San Francisco to explore, in depth, the role of the Forkhead transcription factor FOXO3 (and related FOXOs) in development, aging, and, in particular, exceptional longevity. The presentations covered results derived from model systems, computational analysis and bioinformatics, and genomics and genome-wide association studies of a number of cohorts. Although the data collectively strongly reinforce FOXO3 and the FOXO/FOXO3 pathway as very important determinants in aging and life span, much of the detail of how the latter is achieved still remains unknown, in part, because of the very large number of genes (~2,200 in Caenorhabditis elegans) the transcription factor is involved in helping regulate. Particularly challenging at the present time is understanding the association of apparently nonfunctional specific variants (single nucleotide polymorphisms) of FOXO3 and exceptional longevity in humans, a finding replicated in a number of studies. Nonetheless, as summarized in this report, valuable information and insights were presented at the workshop on the transcription factor including but not limited to its role in determining longevity in C elegans and Drosophila (in flies, eg, an important interaction in aging occurs between dFOXO and the transforming growth factor-β/activin pathway), stem cell function and aging (notably in hematopoiesis), downstream regulatory activity (eg, by binding near sites of RNAse occupancy and altering chromatin structure), and as a potential target for the development a healthy aging drug (in this example, using compounds developed and screened to effect FOXO function in cancer cells).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.