ArticleThe journal of trauma and acute care surgery2014
Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock.
Article in The journal of trauma and acute care surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Characterization of lipidome alterations in a standardized porcine model with multiple trauma and hemorrhagic shock: Are they driven by hepatic injury?The journal of trauma and acute care surgery · 2025Article
- Effect of Triiodothyronine Administration on the Kidney During Haemorrhagic Shock and Resuscitation.Turkish journal of anaesthesiology and reanimation · 2020Article
- Leukotrienes and kidney diseases.Current opinion in nephrology and hypertension · 2018Review
- Tranexamic acid decreases rodent hemorrhagic shock-induced inflammation with mixed end-organ effects.PloS one · 2018Article
- Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock.The journal of trauma and acute care surgery · 2016Article
- Three-minute method for amino acid analysis by UHPLC and high-resolution quadrupole orbitrap mass spectrometry.Amino acids · 2015Article
- A "CLEAN CASE" OF SYSTEMIC INJURY: MESENTERIC LYMPH AFTER HEMORRHAGIC SHOCK ELICITS A STERILE INFLAMMATORY RESPONSE.Shock (Augusta, Ga.) · 2015Article
- Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock.Surgery · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
backgroundEarly acute kidney injury (AKI) following trauma is associated with multiorgan failure and mortality. Leukotrienes have been implicated both in AKI and in acute lung injury. Activated 5-lipoxygenase (5-LO) colocalizes with 5-LO-activating protein (FLAP) in the first step of leukotriene production following trauma and hemorrhagic shock (T/HS). Diversion of postshock mesenteric lymph, which is rich in the 5-LO substrate of arachidonate, attenuates lung injury and decreases 5-LO/FLAP associations in the lung after T/HS. We hypothesized that mesenteric lymph diversion (MLD) will also attenuate postshock 5-LO-mediated AKI.
methodsRats underwent T/HS (laparotomy, hemorrhagic shock to a mean arterial pressure of 30 mm Hg for 45 minutes, and resuscitation), and MLD was accomplished via cannulation of the mesenteric duct. Extent of kidney injury was determined via histology score and verified by urinary neutrophil gelatinase-associated lipocalin assay. Kidney sections were immunostained for 5-LO and FLAP, and colocalization was determined by fluorescence resonance energy transfer signal intensity. The end leukotriene products of 5-LO were determined in urine.
resultsAKI was evident in the T/HS group by derangement in kidney tubule architecture and confirmed by neutrophil gelatinase-associated lipocalin assay, whereas MLD during T/HS preserved renal tubule morphology at a sham level. MLD during T/HS decreased the associations between 5-LO and FLAP demonstrated by fluorescence resonance energy transfer microscopy and decreased leukotriene production in urine.
conclusion5-LO and FLAP colocalize in the interstitium of the renal medulla following T/HS. MLD attenuates this phenomenon, which coincides with pathologic changes seen in tubules during kidney injury and biochemical evidence of AKI. These data suggest that gut-derived leukotriene substrate predisposes the kidney and the lung to subsequent injury.
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