Evidence map›Paper›PMID 24747368›Full record

ReviewSeminars in cell & developmental biology2015

Modulation of tolerogenic dendritic cells and autoimmunity.

Sun Jung Kim, Betty Diamond

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Targeting Talin1 to reprogram dendritic cell activation landscapes: A mechanistically grounded cell therapy for multiple sclerosis model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis.Frontiers in molecular neuroscience · 2019
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Dynamic changes of phenotypes and secretory functions during the differentiation of pre-DCs to mature DCs.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sun Jung KimThe Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, United States.
Betty DiamondThe Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, United States. Electronic address: Bdiamond@nshs.edu.

Funding

Function of Blimp1/prdm-1 in dendritic cells in the generation of autoantibodiesK01AR059378 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI KIM, SUN JUNG · 2010 to 2014
$568k
NIAMS NIH HHS K01 AR059378NIAMS NIH HHS K01AR059378
6 · The paper itself

Abstract

A key function of dendritic cells (DCs) is to induce either immune tolerance or immune activation. Many new DC subsets are being recognized, and it is now clear that each DC subset has a specialized function. For example, different DC subsets may express different cell surface molecules and respond differently to activation by secretion of a unique cytokine profile. Apart from intrinsic differences among DC subsets, various immune modulators in the microenvironment may influence DC function; inappropriate DC function is closely related to the development of immune disorders. The most exciting recent advance in DC biology is appreciation of human DC subsets. In this review, we discuss functionally different mouse and human DC subsets both in lymphoid organs and non-lymphoid organs, the molecules that regulate DC function, and the emerging understanding of the contribution of DCs to autoimmune diseases.

Indexed as

AnimalsAutoimmunityBone Marrow CellsCell DifferentiationCytokinesDendritic CellsHumansImmune ToleranceModels, ImmunologicalTranscription FactorsCytokinesTranscription FactorsAutoimmunityDendritic cellsTissue-resident dendritic cellsTolerogenic dendritic cells

Identifiers

PMID24747368
PMCPMC9973561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.