ArticleCell reports2014
Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
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- Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours inDisease models & mechanisms · 2019Article
- DNA damage and tissue repair: What we can learn from planaria.Seminars in cell & developmental biology · 2019Review
- Enhancer of polycomb maintains germline activity and genome integrity in Drosophila testis.Cell death and differentiation · 2018Article
- Redox-dependent BMI1 activity drives in vivo adult cardiac progenitor cell differentiation.Cell death and differentiation · 2018Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Functional dissection of Drosophila melanogaster SUUR protein influence on H3K27me3 profile.Epigenetics & chromatin · 2017Article
- Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory.Science advances · 2017Article
- Human papillomavirus carcinogenesis: an identity crisis in the retinoblastoma tumor suppressor pathway.Journal of virology · 2015Review
- Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body.Molecular biology of the cell · 2015Article
- Epigenetic regulation of germ cells-remember or forget?Current opinion in genetics & development · 2015Review
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Polycomb group (PcG) proteins establish and maintain genetic programs that regulate cell-fate decisions. Drosophila multi sex combs (mxc) was categorized as a PcG gene based on a classical Polycomb phenotype and genetic interactions; however, a mechanistic connection between Polycomb and Mxc has not been elucidated. Hypomorphic alleles of mxc are characterized by male and female sterility and ectopic sex combs. Mxc is an important regulator of histone synthesis, and we find that increased levels of the core histone H3 in mxc mutants result in replicative stress and a persistent DNA damage response (DDR). Germline loss, ectopic sex combs and the DDR are suppressed by reducing H3 in mxc mutants. Conversely, mxc phenotypes are enhanced when the DDR is abrogated. Importantly, replicative stress induced by hydroxyurea treatment recapitulated mxc germline phenotypes. These data reveal how persistent replicative stress affects gene expression, tissue homeostasis, and maintenance of cellular identity in vivo.
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