ArticleCell reports2014
Conversion of quiescent niche cells to somatic stem cells causes ectopic niche formation in the Drosophila testis.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Cyst stem cell lineage GAL4 transgenes are robustly expressed in hub cells of themicroPublication biology · 2026Article
- Asymmetric Chromosome Establishment and Segregation During Germline Stem Cell Division.Advances in experimental medicine and biology · 2026Review
- A comparison of spermatogenesis between flies and men-conserved processes of male gamete production.Human reproduction update · 2025Review
- Review
- Maintenance of niche architecture requires actomyosin and enables proper stem cell signaling and oriented division in the Drosophila testis.Development (Cambridge, England) · 2025Article
- A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis.Cell proliferation · 2024Article
- Modulating DNA Polα Enhances Cell Reprogramming Across Species.bioRxiv : the preprint server for biology · 2024Article
- Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq ofeLife · 2023Article
- The adult Drosophila testis lacks a mechanism to replenish missing niche cells.Development (Cambridge, England) · 2023Article
- Review
- Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche.Developmental cell · 2022Article
- Article
- EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation ofFrontiers in microbiology · 2022Article
- Stem cell niche signaling goes both ways.Developmental cell · 2021Article
- Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.Developmental cell · 2021Article
- Cellular plasticity at the nexus of development and disease.Development (Cambridge, England) · 2021Review
- A single-cell atlas and lineage analysis of the adult Drosophila ovary.Nature communications · 2020Article
- EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis.Cell reports · 2020Article
- Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle.Current biology : CB · 2019Article
- microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis.The Journal of cell biology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Adult stem cells reside in specialized regulatory microenvironments, or niches, where local signals ensure stem cell maintenance. The Drosophila testis contains a well-characterized niche wherein signals from postmitotic hub cells promote maintenance of adjacent germline stem cells and somatic cyst stem cells (CySCs). Hub cells were considered to be terminally differentiated; here, we show that they can give rise to CySCs. Genetic ablation of CySCs triggers hub cells to transiently exit quiescence, delaminate from the hub, and convert into functional CySCs. Ectopic Cyclin D-Cdk4 expression in hub cells is also sufficient to trigger their conversion into CySCs. In both cases, this conversion causes the formation of multiple ectopic niches over time. Therefore, our work provides a model for understanding how oncogenic mutations in quiescent niche cells could promote loss of quiescence, changes in cell fate, and aberrant niche expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.