Evidence map›Paper›PMID 24746627›Full record

ReviewJournal of controlled release : official journal of the Controlled Release Society2014

Gelatin carriers for drug and cell delivery in tissue engineering.

Marco Santoro, Alexander M Tatara, Antonios G Mikos

Abstract readReview
In one paragraph

Review in Journal of controlled release : official journal of the Controlled Release Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 379 citations in OpenAlex.

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  17. Chondrogenic potential of superficial versus cartilage layer cells of the temporomandibular joint condyle in photopolymerizable gelatin-based hydrogels.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2024
    Article
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marco SantoroDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA.
Alexander M TataraDepartment of Bioengineering, Rice University, Houston, TX 77030, USA.
Antonios G MikosDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA; Department of Bioengineering, Rice University, Houston, TX 77030, USA. Electronic address: mikos@rice.edu.
Rice University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007330 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PLON, SHARON E. · 1985 to 2019
$15.6M
Injectable Cellular Composites for Cartilage EngineeringR01AR048756 · NIAMS · RICE UNIVERSITY · PI KASPER, FRED KURTIS, MIKOS, ANTONIOS G. · 2003 to 2014
$3.3M
Flow Perfusion Bioreactor Fabrication of Bioactive Polymer/ECM Hybrid ConstructsR01AR057083 · NIAMS · RICE UNIVERSITY · PI MIKOS, ANTONIOS G. · 2009 to 2013
$1.6M
NIAMS NIH HHS R01 AR048756NIAMS NIH HHS R01 AR057083NIGMS NIH HHS T32 GM007330
6 · The paper itself

Abstract

The ability of gelatin to form complexes with different drugs has been investigated for controlled release applications. Gelatin parameters, such as crosslinking density and isoelectric point, have been tuned in order to optimize gelatin degradation and drug delivery kinetics. In recent years, focus has shifted away from the use of gelatin in isolation toward the modification of gelatin with functional groups and the fabrication of material composites with embedded gelatin carriers. In this review, we highlight some of the latest work being performed in these areas and comment on trends in the field. Specifically, we discuss gelatin modifications for immune system evasion, drug stabilization, and targeted delivery, as well as gelatin composite systems based on ceramics, naturally-occurring polymers, and synthetic polymers.

Indexed as

Delayed-Action PreparationsDrug CarriersGelatinPolymersTissue EngineeringHumansHydroxyapatitesPolysaccharidesSilkDelayed-Action PreparationsDrug CarriersGelatinHydroxyapatitesPolymersPolysaccharidesSilkCell deliveryComposite materialControlled releaseDrug deliveryGelatin

Identifiers

PMID24746627
PMCPMC4142078
OpenAlexW2019605538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.