ArticleDevelopmental biology2014
Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- The asymmetric Pitx2 gene regulates gut muscular-lacteal development and protects against fatty liver disease.Cell reports · 2021Article
- Biological basis for novel mesothelioma therapies.British journal of cancer · 2021Review
- Mesothelium and Malignant Mesothelioma.Journal of developmental biology · 2019Review
- Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.Cell reports · 2019Article
- The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration.Gut and liver · 2016Review
- Characterisation of Cultured Mesothelial Cells Derived from the Murine Adult Omentum.PloS one · 2016Article
- Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis.The American journal of pathology · 2015Article
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Historically, analyses of mesothelial differentiation have focused on the heart where a highly migratory population of progenitors originating from a localized "extrinsic" source moves to and over the developing organ. This model long stood alone as the paradigm for generation of this cell type. Here, using chick/quail chimeric grafting and subsequent identification of mesothelial cell populations, we demonstrate that a different mechanism for the generation of mesothelia exists in vertebrate organogenesis. In this newly discovered model, mesothelial progenitors are intrinsic to organs of the developing digestive and respiratory systems. Additionally, we demonstrate that the early heart stands alone in its ability to recruit an entirely exogenous mesothelial cell layer during development. Thus, the newly identified "organ intrinsic" model of mesotheliogenesis appears to predominate while the long-studied cardiac model of mesothelial development may be the outlier.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.